The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 52: Heterogeneous nuclear ribonucleoprotein L like

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
24 F1LQ48 (/IPI) P14866 (/IPI) P14866 (/IPI) P14866 (/IPI) P14866 (/IPI) P14866 (/IPI) P14866 (/IPI) P14866 (/IPI) P14866 (/IPI) P14866 (/IPI)
(14 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
21 P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA)
(11 more)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
20 A0A0B4K7B0 (/ISS) A0A0B4K7H8 (/ISS) A0A0B4K7I2 (/ISS) A0A0B4K7I6 (/ISS) A0A0B4K7W3 (/ISS) A0A0B4K7W7 (/ISS) A0A0B4K852 (/ISS) A0A0B4K8A1 (/ISS) A0A0B4K8A2 (/ISS) A0A0B4KEV0 (/ISS)
(10 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
11 P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS)
(1 more)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
11 P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA)
(1 more)
Pre-mRNA intronic binding GO:0097157
Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA).
11 P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA)
(1 more)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
10 Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
3 F1LQ48 (/ISS) Q8R081 (/ISS) Q8R081 (/ISS)
Pre-mRNA intronic binding GO:0097157
Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA).
3 F1LQ48 (/ISS) Q8R081 (/ISS) Q8R081 (/ISS)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
2 Q8R081 (/ISO) Q8R081 (/ISO)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2 Q8R081 (/ISO) Q8R081 (/ISO)
Pre-mRNA intronic binding GO:0097157
Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA).
2 Q8R081 (/ISO) Q8R081 (/ISO)
MRNA CDS binding GO:1990715
Interacting selectively and non-covalently with the coding sequence (CDS) of an mRNA molecule.
2 Q8R081 (/ISO) Q8R081 (/ISO)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 Q921F4 (/ISO)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
1 F1LQ48 (/IDA)
MRNA CDS binding GO:1990715
Interacting selectively and non-covalently with the coding sequence (CDS) of an mRNA molecule.
1 F1LQ48 (/IDA)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
19 A0A0B4K7B0 (/IMP) A0A0B4K7H8 (/IMP) A0A0B4K7I2 (/IMP) A0A0B4K7I6 (/IMP) A0A0B4K7W3 (/IMP) A0A0B4K7W7 (/IMP) A0A0B4K852 (/IMP) A0A0B4K8A1 (/IMP) A0A0B4K8A2 (/IMP) A0A0B4KEV0 (/IMP)
(9 more)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
19 A0A0B4K7B0 (/IMP) A0A0B4K7H8 (/IMP) A0A0B4K7I2 (/IMP) A0A0B4K7I6 (/IMP) A0A0B4K7W3 (/IMP) A0A0B4K7W7 (/IMP) A0A0B4K852 (/IMP) A0A0B4K8A1 (/IMP) A0A0B4K8A2 (/IMP) A0A0B4KEV0 (/IMP)
(9 more)
Adult feeding behavior GO:0008343
Feeding behavior in a fully developed and mature organism.
19 A0A0B4K7B0 (/IMP) A0A0B4K7H8 (/IMP) A0A0B4K7I2 (/IMP) A0A0B4K7I6 (/IMP) A0A0B4K7W3 (/IMP) A0A0B4K7W7 (/IMP) A0A0B4K852 (/IMP) A0A0B4K8A1 (/IMP) A0A0B4K8A2 (/IMP) A0A0B4KEV0 (/IMP)
(9 more)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
13 P14866 (/IMP) P14866 (/IMP) P14866 (/IMP) P14866 (/IMP) P14866 (/IMP) P14866 (/IMP) P14866 (/IMP) P14866 (/IMP) P14866 (/IMP) P14866 (/IMP)
(3 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
11 P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS)
(1 more)
RNA processing GO:0006396
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
11 P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS)
(1 more)
RNA metabolic process GO:0016070
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
11 P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS)
(1 more)
Positive regulation of RNA splicing GO:0033120
Any process that activates or increases the frequency, rate or extent of RNA splicing.
10 Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA) Q8WVV9 (/IDA)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
3 F1LQ48 (/ISS) Q8R081 (/ISS) Q8R081 (/ISS)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
2 Q8R081 (/ISO) Q8R081 (/ISO)
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
2 Q8R081 (/ISO) Q8R081 (/ISO)
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
2 Q8R081 (/ISO) Q8R081 (/ISO)
Negative regulation of mRNA splicing, via spliceosome GO:0048025
Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
2 Q8R081 (/ISO) Q8R081 (/ISO)
Positive regulation of mRNA binding GO:1902416
Any process that activates or increases the frequency, rate or extent of mRNA binding.
2 Q8R081 (/ISO) Q8R081 (/ISO)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 F1LQ48 (/IEP)
Positive regulation of RNA splicing GO:0033120
Any process that activates or increases the frequency, rate or extent of RNA splicing.
1 Q921F4 (/ISO)
Positive regulation of RNA splicing GO:0033120
Any process that activates or increases the frequency, rate or extent of RNA splicing.
1 Q921F4 (/ISS)
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
1 F1LQ48 (/IDA)
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 F1LQ48 (/IMP)
Negative regulation of mRNA splicing, via spliceosome GO:0048025
Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
1 F1LQ48 (/IMP)
Response to peptide GO:1901652
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.
1 F1LQ48 (/IEP)
Positive regulation of mRNA binding GO:1902416
Any process that activates or increases the frequency, rate or extent of mRNA binding.
1 F1LQ48 (/IMP)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
21 P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA)
(11 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
19 A0A0B4K7B0 (/HDA) A0A0B4K7H8 (/HDA) A0A0B4K7I2 (/HDA) A0A0B4K7I6 (/HDA) A0A0B4K7W3 (/HDA) A0A0B4K7W7 (/HDA) A0A0B4K852 (/HDA) A0A0B4K8A1 (/HDA) A0A0B4K8A2 (/HDA) A0A0B4KEV0 (/HDA)
(9 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
12 F1LQ48 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA)
(2 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
12 M0QXS5 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA)
(2 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
11 P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS) P14866 (/TAS)
(1 more)
Ribonucleoprotein granule GO:0035770
A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.
11 P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA)
(1 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
11 P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA) P14866 (/HDA)
(1 more)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
11 P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA) P14866 (/IDA)
(1 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 F1LQ48 (/ISS) Q8R081 (/ISS) Q8R081 (/ISS)
Ribonucleoprotein granule GO:0035770
A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.
3 F1LQ48 (/ISS) Q8R081 (/ISS) Q8R081 (/ISS)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
3 F1LQ48 (/ISS) Q8R081 (/ISS) Q8R081 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q8R081 (/ISO) Q8R081 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q8R081 (/ISO) Q8R081 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q8R081 (/ISO) Q8R081 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q8R081 (/ISO) Q8R081 (/ISO)
Ribonucleoprotein granule GO:0035770
A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.
2 Q8R081 (/ISO) Q8R081 (/ISO)
Pronucleus GO:0045120
The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents.
2 Q8R081 (/IDA) Q8R081 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 Q8R081 (/ISO) Q8R081 (/ISO)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
2 Q8R081 (/ISO) Q8R081 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 F1LQ48 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 F1LQ48 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 F1LQ48 (/IDA)
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