The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14: RNA-binding motif, single-stranded-interacting pro...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Poly(A) binding GO:0008143
Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
9 Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA)
Poly(U) RNA binding GO:0008266
Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule.
9 Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA)
MRNA 3'-UTR AU-rich region binding GO:0035925
Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
9 Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
4 P29558 (/HDA) P29558 (/HDA) P29558 (/HDA) Q15434 (/HDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
3 P29558 (/NAS) P29558 (/NAS) P29558 (/NAS)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
3 P29558 (/NAS) P29558 (/NAS) P29558 (/NAS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
3 P29558 (/NAS) P29558 (/NAS) P29558 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P29558 (/IPI) P29558 (/IPI) P29558 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q15434 (/TAS)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
1 Q8BWL5 (/IDA)
Poly(A) binding GO:0008143
Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
1 Q8BWL5 (/ISO)
Poly(U) RNA binding GO:0008266
Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule.
1 Q8BWL5 (/ISO)
MRNA 3'-UTR AU-rich region binding GO:0035925
Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
1 Q8BWL5 (/ISO)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Defense response to tumor cell GO:0002357
Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism.
9 Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
9 Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
9 Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
9 Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP) Q6XE24 (/IMP)
RNA processing GO:0006396
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
4 P29558 (/TAS) P29558 (/TAS) P29558 (/TAS) Q15434 (/TAS)
Regulation of transforming growth factor beta receptor signaling pathway GO:0017015
Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway.
4 E9QD62 (/IMP) F1Q8Z0 (/IMP) F1QGV3 (/IMP) Q08C34 (/IMP)
Regulation of cartilage development GO:0061035
Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
4 E9QD62 (/IMP) F1Q8Z0 (/IMP) F1QGV3 (/IMP) Q08C34 (/IMP)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
3 P29558 (/NAS) P29558 (/NAS) P29558 (/NAS)
Defense response to tumor cell GO:0002357
Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism.
1 Q8BWL5 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q8BWL5 (/ISO)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q8BWL5 (/ISO)
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 Q8BWL5 (/IDA)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 Q8BWL5 (/ISO)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA) Q6XE24 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 E7ETU5 (/IDA) E7ETU5 (/IDA) E7ETU5 (/IDA) E7ETU5 (/IDA) F6Y5H0 (/IDA) F6Y5H0 (/IDA) P29558 (/IDA) P29558 (/IDA) P29558 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P29558 (/NAS) P29558 (/NAS) P29558 (/NAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8BWL5 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q91W59 (/ISO)
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