The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: CUGBP Elav-like family member 4 isoform 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
BRE binding GO:0042835
Interacting selectively and non-covalently with the RNA element BRE (Bruno response element).
18 Q7TSY6 (/ISS) Q9BZC1 (/ISS) Q9BZC1 (/ISS) Q9BZC1 (/ISS) Q9BZC1 (/ISS) Q9BZC1 (/ISS) Q9BZC1 (/ISS) Q9BZC1 (/ISS) Q9BZC1 (/ISS) Q9BZC1 (/ISS)
(8 more)
Translation repressor activity, mRNA regulatory element binding GO:0000900
Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
17 Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS)
(7 more)
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
17 Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA)
(7 more)
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
9 Q5SZQ8 (/NAS) Q5SZQ8 (/NAS) Q5SZQ8 (/NAS) Q5SZQ8 (/NAS) Q5SZQ8 (/NAS) Q8N6W0 (/NAS) Q8N6W0 (/NAS) Q8N6W0 (/NAS) Q8N6W0 (/NAS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
5 Q5SZQ8 (/IMP) Q5SZQ8 (/IMP) Q5SZQ8 (/IMP) Q5SZQ8 (/IMP) Q5SZQ8 (/IMP)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 M9NF06 (/ISA) Q7K108 (/ISA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q8CIN6 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q8CIN6 (/ISO)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q96J87 (/NAS)
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
1 G5EE68 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 Q7TSY6 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 G5EE68 (/ISS)
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
1 Q7TSY6 (/ISO)
7SK snRNA binding GO:0097322
Interacting selectively and non-covalently with a 7SK small nuclear RNA (7SK snRNA).
1 Q8CIN6 (/IPI)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of mRNA splicing, via spliceosome GO:0048026
Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism.
31 Q08E07 (/ISS) Q08E07 (/ISS) Q08E07 (/ISS) Q0V9L3 (/ISS) Q4R535 (/ISS) Q4R535 (/ISS) Q4R535 (/ISS) Q5NVC8 (/ISS) Q5NVC8 (/ISS) Q5NVC8 (/ISS)
(21 more)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
27 Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q8N6W0 (/IDA) Q8N6W0 (/IDA) Q8N6W0 (/IDA) Q8N6W0 (/IDA) Q96J87 (/IDA)
(17 more)
Positive regulation of mRNA splicing, via spliceosome GO:0048026
Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism.
22 Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA)
(12 more)
Alternative mRNA splicing, via spliceosome GO:0000380
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
17 Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA)
(7 more)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
17 Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS)
(7 more)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
17 Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS) Q9BZC1 (/NAS)
(7 more)
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
5 Q5SZQ8 (/IMP) Q5SZQ8 (/IMP) Q5SZQ8 (/IMP) Q5SZQ8 (/IMP) Q5SZQ8 (/IMP)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
4 D3Z4T1 (/ISO) D3Z580 (/ISO) Q7TSY6 (/ISO) Q8CIN6 (/ISO)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
2 M9NF06 (/ISA) Q7K108 (/ISA)
Positive regulation of mRNA splicing, via spliceosome GO:0048026
Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism.
2 Q7TSY6 (/ISO) Q8CIN6 (/ISO)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
1 G5EE68 (/IMP)
Regulation of neurotransmitter levels GO:0001505
Any process that modulates levels of neurotransmitter.
1 Q7TN33 (/IMP)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 Q7TSY6 (/IMP)
MRNA splice site selection GO:0006376
Selection of a splice site by components of the assembling spliceosome.
1 Q7TSY6 (/IDA)
Synaptic transmission, cholinergic GO:0007271
The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 G5EE68 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q8CIN6 (/IMP)
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
1 Q8CIN6 (/ISO)
MRNA metabolic process GO:0016071
The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
1 G5EE68 (/ISS)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
1 Q8CIN6 (/IMP)
Nuclear body organization GO:0030575
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q8CIN6 (/IMP)
Positive regulation of synaptic transmission, cholinergic GO:0032224
Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.
1 G5EE68 (/IMP)
Positive regulation of synaptic transmission, GABAergic GO:0032230
Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
1 G5EE68 (/IMP)
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
1 G5EE68 (/IMP)
Negative regulation of mRNA splicing, via spliceosome GO:0048025
Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
1 Q7TSY6 (/IMP)
Vocalization behavior GO:0071625
The behavior in which an organism produces sounds by a mechanism involving its respiratory system.
1 Q7TN33 (/IMP)
Negative regulation of excitatory postsynaptic potential GO:0090394
Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
1 Q7TSY6 (/IMP)
NcRNA transcription GO:0098781
The transcription of non (protein) coding RNA from a DNA template.
1 Q8CIN6 (/IMP)
Regulation of retina development in camera-type eye GO:1902866
Any process that modulates the frequency, rate or extent of retina development in camera-type eye.
1 Q7TSY6 (/IEP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
24 Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q7TSY6 (/IDA) Q8CIN6 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA) Q9BZC1 (/IDA)
(14 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q5SZQ8 (/IDA) Q7TN33 (/IDA) Q7TSY6 (/IDA) Q8CIN6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 Q7TSY6 (/ISS) Q8N6W0 (/ISS) Q8N6W0 (/ISS) Q8N6W0 (/ISS) Q8N6W0 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q7TSY6 (/ISO) Q8CIN6 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q96J87 (/NAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8CIN6 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q96J87 (/NAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q96J87 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q8CIN6 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 G5EE68 (/IDA)
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