View in Gene3D

CATH Superfamily 3.30.70.3000

tRNA(His) guanylyltransferase (Thg1)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: tRNA(His) guanylyltransferase (Thg1)

All polymerases and transferases catalyse nucleotide addition in the 5' to 3' direction, except the enzyme tRNA(His) guanylyltransferase (Thg1). Thg1 catalyses the highly unusual 3'-5' addition of a single guanine to the 5'-end of tRNAHis. This reaction is an obligatory step in the maturation of this tRNA. This entry represents the structure of Thg1. It is made of a beta-sheet composed of six antiparallel strands flanked by three or four alpha-helices on each side PMID:21059936.

GO Diversity

Unique GO annotations
24 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
1785 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 57
Domain clusters (>95% seq id): 5
Domain clusters (>35% seq id): 3
Unique PDBs: 14
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 12
Function
Unique EC: 1
Unique GO: 24
Taxonomy
Unique Species: 1785