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CATH Superfamily 3.30.70.260

ACT domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: ACT domain

This entry represents a motif conserved in many allosteric enzymes involved in amino acid and purine biosynthesis, called the ACT domain as the acronym for aspartate kinase, chorismate mutase, and TyrA (prephenate dehydrogenase). Several crystal structures have been determined for proteins that have ACT domains, such as 3-phosphoglycerate dehydrogenase (3PGDH),15 threonine deaminase (TD),16 acetohydroxyacid synthase III,17 and NikR, a transcriptional regulator involved in nickel uptake. The ACT domain consists of 4 beta-strands and 2 alpha-helices PMID:17350037.

GO Diversity

Unique GO annotations
251 Unique GO terms

EC Diversity

Unique EC annotations
19 Unique EC terms

Species Diversity

Unique species annotations
20983 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 335
Domain clusters (>95% seq id): 87
Domain clusters (>35% seq id): 50
Unique PDBs: 119
Alignments
Structural Clusters (5A): 7
Structural Clusters (9A): 3
FunFam Clusters: 192
Function
Unique EC: 19
Unique GO: 251
Taxonomy
Unique Species: 20983