CATH Superfamily 3.30.70.1390
ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2
".
FunFam 4: Leucine-rich repeat kinase, isoform C
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
3 | A0A0B4KH16 (/IDA) A0A0B4KHT3 (/IDA) Q9VDJ9 (/IDA) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
3 | A0A0B4KH16 (/IDA) A0A0B4KHT3 (/IDA) Q9VDJ9 (/IDA) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
3 | A0A0B4KH16 (/IMP) A0A0B4KHT3 (/IMP) Q9VDJ9 (/IMP) |
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
|
3 | A0A0B4KH16 (/IPI) A0A0B4KHT3 (/IPI) Q9VDJ9 (/IPI) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q9VDJ9 (/IPI) |
There are 20 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
|
3 | A0A0B4KH16 (/IMP) A0A0B4KHT3 (/IMP) Q9VDJ9 (/IMP) |
Axo-dendritic transport GO:0008088
The directed movement of organelles or molecules along microtubules in neuron projections.
|
3 | A0A0B4KH16 (/IMP) A0A0B4KHT3 (/IMP) Q9VDJ9 (/IMP) |
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
3 | A0A0B4KH16 (/IDA) A0A0B4KHT3 (/IDA) Q9VDJ9 (/IDA) |
Lysosome localization GO:0032418
Any process in which a lysosome is transported to, and/or maintained in, a specific location.
|
3 | A0A0B4KH16 (/IGI) A0A0B4KHT3 (/IGI) Q9VDJ9 (/IGI) |
Lysosome localization GO:0032418
Any process in which a lysosome is transported to, and/or maintained in, a specific location.
|
3 | A0A0B4KH16 (/IMP) A0A0B4KHT3 (/IMP) Q9VDJ9 (/IMP) |
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
|
3 | A0A0B4KH16 (/IMP) A0A0B4KHT3 (/IMP) Q9VDJ9 (/IMP) |
Retrograde transport, endosome to Golgi GO:0042147
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
|
3 | A0A0B4KH16 (/IGI) A0A0B4KHT3 (/IGI) Q9VDJ9 (/IGI) |
Negative regulation of dendrite morphogenesis GO:0050774
Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis.
|
3 | A0A0B4KH16 (/IMP) A0A0B4KHT3 (/IMP) Q9VDJ9 (/IMP) |
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
|
3 | A0A0B4KH16 (/IMP) A0A0B4KHT3 (/IMP) Q9VDJ9 (/IMP) |
Establishment of Golgi localization GO:0051683
The directed movement of the Golgi to a specific location.
|
3 | A0A0B4KH16 (/IMP) A0A0B4KHT3 (/IMP) Q9VDJ9 (/IMP) |
Regulation of synaptic vesicle endocytosis GO:1900242
Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis.
|
3 | A0A0B4KH16 (/IMP) A0A0B4KHT3 (/IMP) Q9VDJ9 (/IMP) |
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
|
3 | A0A0B4KH16 (/IMP) A0A0B4KHT3 (/IMP) Q9VDJ9 (/IMP) |
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
|
1 | Q9VDJ9 (/IMP) |
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
|
1 | Q9VDJ9 (/IMP) |
Intracellular distribution of mitochondria GO:0048312
Any process that establishes the spatial arrangement of mitochondria within the cell.
|
1 | Q9VDJ9 (/IMP) |
Synaptic vesicle endocytosis GO:0048488
A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
|
1 | A0A0B4KHT3 (/IGI) |
Regulation of microtubule cytoskeleton organization GO:0070507
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
|
1 | Q9VDJ9 (/IMP) |
Regulation of synapse maturation GO:0090128
Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
|
1 | Q9VDJ9 (/IMP) |
Regulation of terminal button organization GO:2000331
Any process that modulates the frequency, rate or extent of terminal button organization.
|
1 | Q9VDJ9 (/IMP) |
Regulation of autophagosome assembly GO:2000785
Any process that modulates the frequency, rate or extent of autophagosome assembly.
|
1 | Q9VDJ9 (/IMP) |
There are 11 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
|
3 | A0A0B4KH16 (/IDA) A0A0B4KHT3 (/IDA) Q9VDJ9 (/IDA) |
Golgi stack GO:0005795
The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.
|
3 | A0A0B4KH16 (/IDA) A0A0B4KHT3 (/IDA) Q9VDJ9 (/IDA) |
Late endosome membrane GO:0031902
The lipid bilayer surrounding a late endosome.
|
3 | A0A0B4KH16 (/IDA) A0A0B4KHT3 (/IDA) Q9VDJ9 (/IDA) |
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
|
3 | A0A0B4KH16 (/IDA) A0A0B4KHT3 (/IDA) Q9VDJ9 (/IDA) |
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
|
3 | A0A0B4KH16 (/IDA) A0A0B4KHT3 (/IDA) Q9VDJ9 (/IDA) |
Dendritic branch point GO:1990033
The part of a dendritic tree where it branches, giving rise to a dendritic branch.
|
3 | A0A0B4KH16 (/IDA) A0A0B4KHT3 (/IDA) Q9VDJ9 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9VDJ9 (/IDA) |
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
1 | Q9VDJ9 (/IDA) |
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
|
1 | A0A0B4KHT3 (/IDA) |
Type I terminal bouton GO:0061174
Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
|
1 | Q9VDJ9 (/IDA) |
Subsynaptic reticulum GO:0071212
An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.
|
1 | A0A0B4KHT3 (/IDA) |