The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Nucleotide cyclase
".
FunFam 51: Soluble guanylate cyclase 88E
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
1 | Q8INF0 (/IDA) |
|
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
|
1 | Q8INF0 (/IDA) |
|
Oxygen binding GO:0019825
Interacting selectively and non-covalently with oxygen (O2).
|
1 | Q8INF0 (/IDA) |
|
Oxygen sensor activity GO:0019826
Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2).
|
1 | Q8INF0 (/IDA) |
|
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
|
1 | Q8INF0 (/IDA) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q8INF0 (/IPI) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | Q8INF0 (/IPI) |
|
Carbon monoxide binding GO:0070025
Interacting selectively and non-covalently with carbon monoxide (CO).
|
1 | Q8INF0 (/IDA) |
|
Nitric oxide binding GO:0070026
Interacting selectively and non-covalently with nitric oxide (NO).
|
1 | Q8INF0 (/IDA) |
There are 4 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
|
1 | Q8INF0 (/IDA) |
|
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | Q8INF0 (/IMP) |
|
CGMP-mediated signaling GO:0019934
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
|
1 | Q8INF0 (/IDA) |
|
Nitric oxide-cGMP-mediated signaling pathway GO:0038060
Any intracellular signal transduction in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP.
|
1 | Q8INF0 (/IDA) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Guanylate cyclase complex, soluble GO:0008074
Complex that possesses guanylate cyclase activity and is not bound to a membrane.
|
1 | Q8INF0 (/IC) |
|
Guanylate cyclase complex, soluble GO:0008074
Complex that possesses guanylate cyclase activity and is not bound to a membrane.
|
1 | Q8INF0 (/IDA) |