The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleotide cyclase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: Adenylate cyclase type 10

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Adenylate cyclase activity GO:0004016
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
3 Q96PN6 (/IDA) Q96PN6 (/IDA) Q9Z286 (/IDA)
Adenylate cyclase activity GO:0004016
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
3 Q8C0T9 (/TAS) Q96PN6 (/TAS) Q96PN6 (/TAS)
Bicarbonate binding GO:0071890
Interacting selectively and non-covalently with bicarbonate (CHO3-) ions.
3 Q866F4 (/ISS) Q8C0T9 (/ISS) Q9Z286 (/ISS)
Adenylate cyclase activity GO:0004016
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
2 Q866F4 (/ISS) Q8C0T9 (/ISS)
Adenylate cyclase activity GO:0004016
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
2 Q96PN6 (/NAS) Q96PN6 (/NAS)
Bicarbonate binding GO:0071890
Interacting selectively and non-covalently with bicarbonate (CHO3-) ions.
2 Q96PN6 (/IDA) Q96PN6 (/IDA)
Adenylate cyclase activity GO:0004016
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
1 Q8C0T9 (/ISO)
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
1 Q551V8 (/IDA)
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
1 Q551V8 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q8C0T9 (/IPI)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
1 Q9Z286 (/IDA)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
1 Q8C0T9 (/ISO)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
1 Q9Z286 (/IPI)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
1 Q8C0T9 (/ISO)
Bicarbonate binding GO:0071890
Interacting selectively and non-covalently with bicarbonate (CHO3-) ions.
1 Q8C0T9 (/ISO)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Epithelial cilium movement involved in extracellular fluid movement GO:0003351
The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.
3 Q866F4 (/ISS) Q8C0T9 (/ISS) Q9Z286 (/ISS)
CAMP biosynthetic process GO:0006171
The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
3 Q96PN6 (/IDA) Q96PN6 (/IDA) Q9Z286 (/IDA)
Cellular response to inorganic substance GO:0071241
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
3 Q866F4 (/ISS) Q8C0T9 (/ISS) Q9Z286 (/ISS)
Epithelial cilium movement involved in extracellular fluid movement GO:0003351
The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.
2 Q96PN6 (/IMP) Q96PN6 (/IMP)
CAMP biosynthetic process GO:0006171
The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
2 Q866F4 (/ISS) Q8C0T9 (/ISS)
CAMP biosynthetic process GO:0006171
The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
2 Q96PN6 (/NAS) Q96PN6 (/NAS)
Cellular response to inorganic substance GO:0071241
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
2 Q96PN6 (/IDA) Q96PN6 (/IDA)
Epithelial cilium movement involved in extracellular fluid movement GO:0003351
The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.
1 Q8C0T9 (/ISO)
CAMP biosynthetic process GO:0006171
The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
1 Q9Z286 (/IMP)
CAMP biosynthetic process GO:0006171
The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
1 Q8C0T9 (/ISO)
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q551V8 (/IGI)
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q551V8 (/IMP)
CGMP-mediated signaling GO:0019934
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
1 Q551V8 (/IDA)
Myosin filament organization GO:0031033
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules.
1 Q551V8 (/IGI)
Myosin II filament disassembly GO:0031037
The disassembly of a bipolar filament composed of myosin II molecules.
1 Q551V8 (/TAS)
Negative regulation of lateral pseudopodium assembly GO:0031276
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell.
1 Q551V8 (/IGI)
Negative regulation of lateral pseudopodium assembly GO:0031276
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell.
1 Q551V8 (/TAS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q9Z286 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q8C0T9 (/ISO)
Chemotaxis to cAMP GO:0043327
The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP.
1 Q551V8 (/IGI)
Regulation of chemotaxis GO:0050920
Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
1 Q551V8 (/IGI)
Response to electrical stimulus GO:0051602
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
1 Q551V8 (/IGI)
Cellular response to inorganic substance GO:0071241
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
1 Q8C0T9 (/ISO)

There are 28 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q866F4 (/ISS) Q8C0T9 (/ISS) Q9Z286 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q8C0T9 (/TAS) Q96PN6 (/TAS) Q96PN6 (/TAS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
3 Q866F4 (/ISS) Q8C0T9 (/ISS) Q9Z286 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q96PN6 (/IDA) Q96PN6 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q551V8 (/IDA) Q9Z286 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q96PN6 (/NAS) Q96PN6 (/NAS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 Q96PN6 (/IDA) Q96PN6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8C0T9 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9Z286 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8C0T9 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8C0T9 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8C0T9 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q8C0T9 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q9Z286 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q8C0T9 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q9Z286 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q8C0T9 (/ISO)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 Q9Z286 (/IDA)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 Q8C0T9 (/ISO)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
1 Q551V8 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q9Z286 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q8C0T9 (/ISO)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 Q9Z286 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 Q8C0T9 (/ISO)
Basal part of cell GO:0045178
The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.
1 Q9Z286 (/IDA)
Basal part of cell GO:0045178
The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.
1 Q8C0T9 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q8C0T9 (/ISO)
Cell leading edge cell cortex GO:1904269
The cell cortex of the leading edge of a cell.
1 Q551V8 (/IDA)
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