The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EIF_2_alpha
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Eukaryotic translation initiation factor 2 alpha s...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
11 Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS)
(1 more)

There are 1 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
11 Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS)
(1 more)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Eukaryotic translation initiation factor 2 complex GO:0005850
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.
11 Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS) Q8IBH7 (/ISS)
(1 more)
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