The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Bacterial Topoisomerase I, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: DNA topoisomerase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA topoisomerase activity GO:0003916
Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
58 P06612 (/IMP) P06612 (/IMP) P06612 (/IMP) P06612 (/IMP) P06612 (/IMP) P06612 (/IMP) P06612 (/IMP) P06612 (/IMP) P06612 (/IMP) P06612 (/IMP)
(48 more)
DNA topoisomerase type I activity GO:0003917
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
58 P06612 (/IMP) P06612 (/IMP) P06612 (/IMP) P06612 (/IMP) P06612 (/IMP) P06612 (/IMP) P06612 (/IMP) P06612 (/IMP) P06612 (/IMP) P06612 (/IMP)
(48 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
58 P06612 (/IPI) P06612 (/IPI) P06612 (/IPI) P06612 (/IPI) P06612 (/IPI) P06612 (/IPI) P06612 (/IPI) P06612 (/IPI) P06612 (/IPI) P06612 (/IPI)
(48 more)
DNA topoisomerase type I activity GO:0003917
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
4 Q9KRB2 (/ISS) Q9KRB2 (/ISS) Q9KRB2 (/ISS) Q9KRB2 (/ISS)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
58 P06612 (/IGI) P06612 (/IGI) P06612 (/IGI) P06612 (/IGI) P06612 (/IGI) P06612 (/IGI) P06612 (/IGI) P06612 (/IGI) P06612 (/IGI) P06612 (/IGI)
(48 more)
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
4 Q9KRB2 (/ISS) Q9KRB2 (/ISS) Q9KRB2 (/ISS) Q9KRB2 (/ISS)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
58 P06612 (/IDA) P06612 (/IDA) P06612 (/IDA) P06612 (/IDA) P06612 (/IDA) P06612 (/IDA) P06612 (/IDA) P06612 (/IDA) P06612 (/IDA) P06612 (/IDA)
(48 more)
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