The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Nef Regulatory Factor
".
FunFam 1: Protein Nef
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 15 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
7 | O40177 (/ISS) P03404 (/ISS) P04324 (/ISS) Q70627 (/ISS) Q90VU7 (/ISS) Q9WLM4 (/ISS) Q9WM24 (/ISS) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
7 | O40177 (/ISS) P03404 (/ISS) P04324 (/ISS) Q70627 (/ISS) Q90VU7 (/ISS) Q9WLM4 (/ISS) Q9WM24 (/ISS) |
|
Thioesterase binding GO:0031996
Interacting selectively and non-covalently with any thioesterase enzyme.
|
7 | O40177 (/ISS) P03404 (/ISS) P04324 (/ISS) Q70627 (/ISS) Q90VU7 (/ISS) Q9WLM4 (/ISS) Q9WM24 (/ISS) |
|
MHC class I protein binding GO:0042288
Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
|
7 | O40177 (/ISS) P03404 (/ISS) P04324 (/ISS) Q70627 (/ISS) Q90VU7 (/ISS) Q9WLM4 (/ISS) Q9WM24 (/ISS) |
|
CD4 receptor binding GO:0042609
Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages.
|
7 | O40177 (/ISS) P03404 (/ISS) P04324 (/ISS) Q70627 (/ISS) Q90VU7 (/ISS) Q9WLM4 (/ISS) Q9WM24 (/ISS) |
|
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
|
7 | O40177 (/ISS) P03404 (/ISS) P04324 (/ISS) Q70627 (/ISS) Q90VU7 (/ISS) Q9WLM4 (/ISS) Q9WM24 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | P03404 (/IPI) P03406 (/IPI) P03407 (/IPI) P04601 (/IPI) Q90VU7 (/IPI) Q9QPN3 (/IPI) |
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | P03406 (/IPI) |
|
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
|
1 | P03406 (/IPI) |
|
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
|
1 | P03406 (/IPI) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | P03406 (/IPI) |
|
Thioesterase binding GO:0031996
Interacting selectively and non-covalently with any thioesterase enzyme.
|
1 | P03406 (/IPI) |
|
MHC class I protein binding GO:0042288
Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
|
1 | P03406 (/IPI) |
|
CD4 receptor binding GO:0042609
Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages.
|
1 | P03406 (/IPI) |
|
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
|
1 | P03406 (/IPI) |
There are 22 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
|
7 | O40177 (/ISS) P03404 (/ISS) P04324 (/ISS) Q70627 (/ISS) Q90VU7 (/ISS) Q9WLM4 (/ISS) Q9WM24 (/ISS) |
|
Viral life cycle GO:0019058
A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome.
|
7 | O40177 (/ISS) P03404 (/ISS) P04324 (/ISS) Q70627 (/ISS) Q90VU7 (/ISS) Q9WLM4 (/ISS) Q9WM24 (/ISS) |
|
Negative regulation of CD4 biosynthetic process GO:0045225
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.
|
7 | O40177 (/ISS) P03404 (/ISS) P04324 (/ISS) Q70627 (/ISS) Q90VU7 (/ISS) Q9WLM4 (/ISS) Q9WM24 (/ISS) |
|
Suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I GO:0046776
Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.
|
7 | O40177 (/ISS) P03404 (/ISS) P04324 (/ISS) Q70627 (/ISS) Q90VU7 (/ISS) Q9WLM4 (/ISS) Q9WM24 (/ISS) |
|
Regulation of calcium-mediated signaling GO:0050848
Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.
|
7 | O40177 (/ISS) P03404 (/ISS) P04324 (/ISS) Q70627 (/ISS) Q90VU7 (/ISS) Q9WLM4 (/ISS) Q9WM24 (/ISS) |
|
Negative regulation by symbiont of host T-cell mediated immune response GO:0052085
Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
7 | O40177 (/ISS) P03404 (/ISS) P04324 (/ISS) Q70627 (/ISS) Q90VU7 (/ISS) Q9WLM4 (/ISS) Q9WM24 (/ISS) |
|
Activation of transmembrane receptor protein tyrosine kinase activity GO:0007171
Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity.
|
1 | P03407 (/IDA) |
|
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
|
1 | P03406 (/IDA) |
|
Viral life cycle GO:0019058
A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome.
|
1 | P03406 (/IDA) |
|
Viral life cycle GO:0019058
A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome.
|
1 | P04601 (/TAS) |
|
Uncoating of virus GO:0019061
The process by which an incoming virus is disassembled in the host cell to release a replication-competent viral genome.
|
1 | P04601 (/TAS) |
|
Fusion of virus membrane with host plasma membrane GO:0019064
Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm.
|
1 | P04601 (/TAS) |
|
Virion assembly GO:0019068
A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed.
|
1 | P04601 (/TAS) |
|
Entry into host cell GO:0030260
The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
1 | P04601 (/TAS) |
|
Positive regulation of catalytic activity in other organism involved in symbiotic interaction GO:0043946
Any process in which an organism activates, maintains or increases the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction.
|
1 | P03406 (/IDA) |
|
Negative regulation of CD4 biosynthetic process GO:0045225
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.
|
1 | P03406 (/IDA) |
|
Suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I GO:0046776
Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.
|
1 | P03406 (/IDA) |
|
Regulation of defense response to virus by virus GO:0050690
Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism.
|
1 | P04601 (/TAS) |
|
Regulation of calcium-mediated signaling GO:0050848
Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.
|
1 | P03406 (/IC) |
|
Regulation of calcium-mediated signaling GO:0050848
Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.
|
1 | P03406 (/IDA) |
|
Regulation of T cell activation GO:0050863
Any process that modulates the frequency, rate or extent of T cell activation.
|
1 | P03406 (/NAS) |
|
Negative regulation by symbiont of host T-cell mediated immune response GO:0052085
Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
1 | P03406 (/IDA) |
There are 0 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.