The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Non-specific serine/threonine protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 O54874 (/IPI) Q3UU96 (/IPI) Q5VT25 (/IPI) Q7TT49 (/IPI) Q7TT50 (/IPI) Q9W1B0 (/IPI)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
5 Q7TT49 (/ISS) Q7TT50 (/ISS) Q9W1B0 (/ISS) Q9Y5S2 (/ISS) Q9Y5S2 (/ISS)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
4 Q7TT49 (/ISS) Q7TT50 (/ISS) Q9Y5S2 (/ISS) Q9Y5S2 (/ISS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
4 O54874 (/IDA) Q5VT25 (/IDA) Q7TT49 (/IDA) Q9W1B0 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
4 Q7TT49 (/ISS) Q7TT50 (/ISS) Q9Y5S2 (/ISS) Q9Y5S2 (/ISS)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
3 Q9W1B0 (/IDA) Q9Y5S2 (/IDA) Q9Y5S2 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
2 O54874 (/IDA) Q5VT25 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
2 Q9Y5S2 (/TAS) Q9Y5S2 (/TAS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 Q3UU96 (/ISO) Q7TT50 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 O54874 (/IDA) Q5VT25 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 O54874 (/IPI) Q5VT25 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 Q9Y5S2 (/IPI) Q9Y5S2 (/IPI)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 Q3UU96 (/ISO)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 Q7TT50 (/ISO)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 Q5VT25 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q3UU96 (/ISO)
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
1 Q7TT49 (/IDA)
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
1 Q7TT50 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q3UU96 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q7TT50 (/ISO)

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
5 O54874 (/IDA) Q5VT25 (/IDA) Q7TT49 (/IDA) Q9Y5S2 (/IDA) Q9Y5S2 (/IDA)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
5 O54874 (/IMP) Q5VT25 (/IMP) Q7TT49 (/IMP) Q9Y5S2 (/IMP) Q9Y5S2 (/IMP)
Actomyosin structure organization GO:0031032
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.
5 O54874 (/IMP) Q5VT25 (/IMP) Q7TT49 (/IMP) Q9Y5S2 (/IMP) Q9Y5S2 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
4 Q7TT49 (/ISS) Q7TT50 (/ISS) Q9Y5S2 (/ISS) Q9Y5S2 (/ISS)
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
4 Q7TT49 (/ISS) Q7TT50 (/ISS) Q9Y5S2 (/ISS) Q9Y5S2 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 Q3UU96 (/ISO) Q7TT50 (/ISO)
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
2 Q9Y5S2 (/TAS) Q9Y5S2 (/TAS)
Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
2 Q9Y5S2 (/TAS) Q9Y5S2 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 Q9Y5S2 (/TAS) Q9Y5S2 (/TAS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 Q3UU96 (/ISO) Q7TT50 (/ISO)
Actomyosin structure organization GO:0031032
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.
2 Q3UU96 (/ISO) Q7TT50 (/ISO)
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
2 O54874 (/IDA) Q5VT25 (/IDA)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
1 Q3UU96 (/IMP)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 O01583 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q5VT25 (/TAS)
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
1 O54874 (/IDA)
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
1 Q3UU96 (/ISO)
Nuclear migration GO:0007097
The directed movement of the nucleus to a specific location within a cell.
1 Q3UU96 (/IMP)
Synaptic target recognition GO:0008039
The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.
1 Q9W1B0 (/IMP)
Actin polymerization or depolymerization GO:0008154
Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
1 Q9W1B0 (/IMP)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
1 O01583 (/IGI)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
1 O01583 (/IMP)
Embryonic body morphogenesis GO:0010172
The process in which the anatomical structures of the embryonic soma are generated and organized.
1 O01583 (/IGI)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q7TT49 (/IMP)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q7TT50 (/ISO)
Regulation of actin filament polymerization GO:0030833
Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
1 Q9W1B0 (/IMP)
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q3UU96 (/ISO)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 O01583 (/IMP)
Embryonic morphogenesis GO:0048598
The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
1 O01583 (/IGI)
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
1 O54874 (/IDA)
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
1 Q3UU96 (/ISO)
Epithelial tube morphogenesis GO:0060562
The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
1 O01583 (/IMP)
Regulation of Golgi organization GO:1903358
Any process that modulates the frequency, rate or extent of Golgi organization.
1 O01583 (/IMP)
Positive regulation of endocytic recycling GO:2001137
Any process that activates or increases the frequency, rate or extent of endocytic recycling.
1 O01583 (/IMP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
6 O54874 (/ISS) Q5VT25 (/ISS) Q7TT49 (/ISS) Q7TT50 (/ISS) Q9Y5S2 (/ISS) Q9Y5S2 (/ISS)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
5 Q5VT25 (/ISS) Q7TT49 (/ISS) Q7TT50 (/ISS) Q9Y5S2 (/ISS) Q9Y5S2 (/ISS)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
5 Q5VT25 (/ISS) Q7TT49 (/ISS) Q7TT50 (/ISS) Q9Y5S2 (/ISS) Q9Y5S2 (/ISS)
Actomyosin GO:0042641
Any complex of actin, myosin, and accessory proteins.
5 O54874 (/IDA) Q5VT25 (/IDA) Q7TT49 (/IDA) Q9Y5S2 (/IDA) Q9Y5S2 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 Q5VT25 (/HDA) Q9Y5S2 (/HDA) Q9Y5S2 (/HDA)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2 Q9Y5S2 (/TAS) Q9Y5S2 (/TAS)
Actomyosin GO:0042641
Any complex of actin, myosin, and accessory proteins.
2 Q3UU96 (/ISO) Q7TT50 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O01583 (/IDA)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 O54874 (/IDA)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 Q3UU96 (/ISO)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q3UU96 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q9W1B0 (/IDA)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 Q9W1B0 (/IDA)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
1 O54874 (/IDA)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
1 Q3UU96 (/ISO)