The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Thymidylate synthase/dCMP hydroxymethylase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Bifunctional dihydrofolate reductase-thymidylate s...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Thymidylate synthase. [EC: 2.1.1.45]
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
    3 P07382 P16126 Q27783
    Dihydrofolate reductase. [EC: 1.5.1.3]
    5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
    • The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate.
    • Formerly EC 1.5.1.4.
    3 P07382 P16126 Q27783