The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Thymidylate synthase/dCMP hydroxymethylase domain
".
FunFam 1: Thymidylate synthase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Thymidylate synthase activity GO:0004799
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate.
|
162 |
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
(152 more) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
154 |
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
(144 more) |
|
Thymidylate synthase activity GO:0004799
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate.
|
17 |
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
(7 more) |
There are 4 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DTMP biosynthetic process GO:0006231
The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate).
|
162 |
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
(152 more) |
|
Response to radiation GO:0009314
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
|
154 |
P0A884 (/IMP)
P0A884 (/IMP)
P0A884 (/IMP)
P0A884 (/IMP)
P0A884 (/IMP)
P0A884 (/IMP)
P0A884 (/IMP)
P0A884 (/IMP)
P0A884 (/IMP)
P0A884 (/IMP)
(144 more) |
|
2'-deoxyribonucleotide biosynthetic process GO:0009265
The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
|
17 |
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
Q81R23 (/ISS)
(7 more) |
|
DUMP catabolic process GO:0046079
The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate.
|
8 | P9WFR9 (/IDA) P9WFR9 (/IDA) P9WFR9 (/IDA) P9WFR9 (/IDA) P9WFR9 (/IDA) P9WFR9 (/IDA) P9WFR9 (/IDA) P9WFR9 (/IDA) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
154 |
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
P0A884 (/IDA)
(144 more) |
