The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Histidine kinase-like ATPase, C-terminal domain
".
FunFam 50: Histidine kinase 4
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 17 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein histidine kinase activity GO:0004673
Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.
|
7 | A1A698 (/IDA) A1A699 (/IDA) A1A699 (/IDA) Q9C5U0 (/IDA) Q9C5U1 (/IDA) Q9C5U1 (/IDA) Q9C5U2 (/IDA) |
|
Protein histidine kinase activity GO:0004673
Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.
|
4 | Q75WE8 (/RCA) Q75WE8 (/RCA) Q76GZ9 (/RCA) Q9FRY7 (/RCA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | Q9C5U0 (/IPI) Q9C5U1 (/IPI) Q9C5U1 (/IPI) Q9C5U2 (/IPI) |
|
Cytokinin receptor activity GO:0009884
Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
4 | Q9C5U0 (/TAS) Q9C5U1 (/TAS) Q9C5U1 (/TAS) Q9C5U2 (/TAS) |
|
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
|
4 | Q75WE8 (/RCA) Q75WE8 (/RCA) Q76GZ9 (/RCA) Q9FRY7 (/RCA) |
|
Protein histidine kinase binding GO:0043424
Interacting selectively and non-covalently with protein histidine kinase.
|
4 | Q9C5U0 (/IPI) Q9C5U1 (/IPI) Q9C5U1 (/IPI) Q9C5U2 (/IPI) |
|
Phosphorelay sensor kinase activity GO:0000155
Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
|
3 | A1A698 (/IDA) A1A699 (/IDA) A1A699 (/IDA) |
|
Transmembrane histidine kinase cytokinin receptor activity GO:0009885
Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate.
|
3 | Q76GZ9 (/IDA) Q9C5U0 (/IDA) Q9FRY7 (/IDA) |
|
Cytokine binding GO:0019955
Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
|
3 | A1A698 (/IDA) A1A699 (/IDA) A1A699 (/IDA) |
|
Protein histidine kinase activity GO:0004673
Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.
|
2 | Q9C5U1 (/IMP) Q9C5U1 (/IMP) |
|
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
|
2 | Q76GZ9 (/IDA) Q9FRY7 (/IDA) |
|
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
|
1 | Q9C5U0 (/IDA) |
|
Cytokinin receptor activity GO:0009884
Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | Q9C5U0 (/IDA) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | Q9C5U0 (/IPI) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | Q9C5U2 (/IPI) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | Q9C5U0 (/IPI) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q9C5U2 (/IPI) |
There are 31 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
|
4 | Q9C5U0 (/IEP) Q9C5U1 (/IEP) Q9C5U1 (/IEP) Q9C5U2 (/IEP) |
|
Cytokinin-activated signaling pathway GO:0009736
A series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription.
|
4 | Q9C5U0 (/TAS) Q9C5U1 (/TAS) Q9C5U1 (/TAS) Q9C5U2 (/TAS) |
|
Regulation of seed germination GO:0010029
Any process that modulates the frequency, rate or extent of seed germination.
|
4 | Q9C5U0 (/IMP) Q9C5U1 (/IMP) Q9C5U1 (/IMP) Q9C5U2 (/IMP) |
|
Regulation of meristem development GO:0048509
Any process that modulates the frequency, rate or extent of meristem development, the biological process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure.
|
4 | Q9C5U0 (/IMP) Q9C5U1 (/IMP) Q9C5U1 (/IMP) Q9C5U2 (/IMP) |
|
Regulation of shoot system development GO:0048831
Any process that modulates the frequency, rate or extent of shoot development.
|
4 | Q9C5U0 (/IMP) Q9C5U1 (/IMP) Q9C5U1 (/IMP) Q9C5U2 (/IMP) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
3 | A1A698 (/IDA) A1A699 (/IDA) A1A699 (/IDA) |
|
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
|
3 | Q9C5U1 (/IMP) Q9C5U1 (/IMP) Q9C5U2 (/IMP) |
|
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
|
3 | Q9C5U1 (/IEP) Q9C5U1 (/IEP) Q9C5U2 (/IEP) |
|
Regulation of flower development GO:0009909
Any process that modulates the frequency, rate or extent of flower development.
|
3 | Q9C5U1 (/IMP) Q9C5U1 (/IMP) Q9C5U2 (/IMP) |
|
Phloem or xylem histogenesis GO:0010087
The process whose specific outcome is the progression of phloem and/or xylem over time, from formation to the mature structure. An example of this process is found in Arabidopsis thaliana.
|
3 | Q9C5U1 (/IMP) Q9C5U1 (/IMP) Q9C5U2 (/IMP) |
|
Regulation of chlorophyll catabolic process GO:0010271
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of chlorophyll.
|
3 | Q9C5U1 (/IMP) Q9C5U1 (/IMP) Q9C5U2 (/IMP) |
|
Cellular response to phosphate starvation GO:0016036
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate.
|
3 | Q9C5U0 (/IMP) Q9C5U1 (/IMP) Q9C5U1 (/IMP) |
|
Negative regulation of iron ion transport GO:0034757
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
3 | Q9C5U1 (/IMP) Q9C5U1 (/IMP) Q9C5U2 (/IMP) |
|
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
|
3 | Q9C5U0 (/IDA) Q9C5U1 (/IDA) Q9C5U1 (/IDA) |
|
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
|
3 | Q9C5U0 (/IMP) Q9C5U1 (/IMP) Q9C5U1 (/IMP) |
|
Cellular response to cold GO:0070417
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
|
3 | Q9C5U1 (/IMP) Q9C5U1 (/IMP) Q9C5U2 (/IMP) |
|
Cellular response to abscisic acid stimulus GO:0071215
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
|
3 | Q9C5U1 (/IMP) Q9C5U1 (/IMP) Q9C5U2 (/IMP) |
|
Cellular response to sucrose stimulus GO:0071329
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus.
|
3 | Q9C5U0 (/IMP) Q9C5U1 (/IMP) Q9C5U1 (/IMP) |
|
Secondary growth GO:0080117
Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of secondary vascular tissues by the vascular cambium.
|
3 | Q9C5U1 (/IMP) Q9C5U1 (/IMP) Q9C5U2 (/IMP) |
|
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
|
2 | Q9C5U1 (/IEP) Q9C5U1 (/IEP) |
|
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
|
2 | Q76GZ9 (/IDA) Q9FRY7 (/IDA) |
|
Cytokinin-activated signaling pathway GO:0009736
A series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q76GZ9 (/IDA) Q9FRY7 (/IDA) |
|
Leaf senescence GO:0010150
The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism.
|
2 | Q9C5U1 (/IMP) Q9C5U1 (/IMP) |
|
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
|
1 | Q9C5U0 (/IDA) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | Q9C5U0 (/IGI) |
|
Osmosensory signaling pathway GO:0007231
The series of molecular signals initiated in response to osmotic change.
|
1 | Q9C5U0 (/IMP) |
|
Sulfate transport GO:0008272
The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q9C5U0 (/IMP) |
|
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
|
1 | Q9C5U2 (/IMP) |
|
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
|
1 | Q9C5U2 (/IEP) |
|
Embryonic root morphogenesis GO:0010086
The process in which the anatomical structures of the embryonic root are generated and organized.
|
1 | Q9C5U0 (/IMP) |
|
Carbohydrate homeostasis GO:0033500
A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell.
|
1 | Q9C5U0 (/IMP) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | Q9C5U0 (/ISS) Q9C5U1 (/ISS) Q9C5U1 (/ISS) Q9C5U2 (/ISS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
4 | Q75WE8 (/RCA) Q75WE8 (/RCA) Q76GZ9 (/RCA) Q9FRY7 (/RCA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q9C5U1 (/IDA) Q9C5U1 (/IDA) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | Q9C5U0 (/IDA) |
