The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Histidine kinase-like ATPase, C-terminal domain
".
FunFam 2: DNA gyrase subunit B
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
219 |
P0AES6 (/IPI)
P0AES6 (/IPI)
P0AES6 (/IPI)
P0AES6 (/IPI)
P0AES6 (/IPI)
P0AES6 (/IPI)
P0AES6 (/IPI)
P0AES6 (/IPI)
P0AES6 (/IPI)
P0AES6 (/IPI)
(209 more) |
|
DNA supercoiling activity GO:0034335
Catalytic introduction of supercoils in a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.
|
131 |
A0A0G2Q9D6 (/IDA)
A0A0G2Q9D6 (/IDA)
A0A0G2Q9D6 (/IDA)
A0A0G2Q9D6 (/IDA)
A0QNE0 (/IDA)
A0QNE0 (/IDA)
A0QNE0 (/IDA)
C5C7X8 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
(121 more) |
|
DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0003918
Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
|
121 |
C5C7X8 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
(111 more) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
117 |
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
(107 more) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
112 |
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
(102 more) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
112 |
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
(102 more) |
|
DNA-dependent ATPase activity GO:0008094
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.
|
112 |
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
(102 more) |
|
DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0003918
Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
|
15 |
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KVX3 (/ISS)
(5 more) |
|
DNA topoisomerase activity GO:0003916
Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
|
6 | Q9KVX3 (/ISS) Q9KVX3 (/ISS) Q9KVX3 (/ISS) Q9KVX3 (/ISS) Q9KVX3 (/ISS) Q9KVX3 (/ISS) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
5 | P9WG45 (/IDA) P9WG45 (/IDA) P9WG45 (/IDA) P9WG45 (/IDA) P9WG45 (/IDA) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
|
112 |
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
(102 more) |
|
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
|
112 |
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
P0AES6 (/IMP)
(102 more) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
112 |
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
(102 more) |
|
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
|
102 |
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
(92 more) |
|
Plasmid partitioning GO:0030541
Any process in which plasmids are segregated or distributed into daughter cells upon cell division.
|
102 |
P20083 (/IDA)
P20083 (/IDA)
P20083 (/IDA)
P20083 (/IDA)
P20083 (/IDA)
P20083 (/IDA)
P20083 (/IDA)
P20083 (/IDA)
P20083 (/IDA)
P20083 (/IDA)
(92 more) |
|
Chromosome organization GO:0051276
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
|
102 |
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
P20083 (/IMP)
(92 more) |
|
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
|
15 |
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KPD9 (/ISS)
Q9KVX3 (/ISS)
(5 more) |
|
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
|
9 | Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) |
|
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
|
9 | Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) |
|
SOS response GO:0009432
An error-prone process for repairing damaged microbial DNA.
|
5 | Q92QA5 (/EXP) Q92QA5 (/EXP) Q92QA5 (/EXP) Q92QA5 (/EXP) Q92QA5 (/EXP) |
|
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
|
3 | Q9HUJ8 (/IDA) Q9HUJ8 (/IDA) Q9HUJ8 (/IDA) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
214 |
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
(204 more) |
|
DNA topoisomerase complex (ATP-hydrolyzing) GO:0009330
Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity.
|
113 |
O67137 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
(103 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
112 |
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
P0AES6 (/IDA)
(102 more) |
|
DNA topoisomerase IV complex GO:0009340
A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA.
|
9 | Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) |
|
DNA topoisomerase complex (ATP-hydrolyzing) GO:0009330
Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity.
|
6 | Q9KVX3 (/ISS) Q9KVX3 (/ISS) Q9KVX3 (/ISS) Q9KVX3 (/ISS) Q9KVX3 (/ISS) Q9KVX3 (/ISS) |
|
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
|
5 | P9WG45 (/HDA) P9WG45 (/HDA) P9WG45 (/HDA) P9WG45 (/HDA) P9WG45 (/HDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | P9WG45 (/HDA) P9WG45 (/HDA) P9WG45 (/HDA) P9WG45 (/HDA) P9WG45 (/HDA) |
|
DNA topoisomerase IV complex GO:0009340
A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA.
|
3 | Q9HUJ8 (/IDA) Q9HUJ8 (/IDA) Q9HUJ8 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q94BZ7 (/IDA) |
|
DNA topoisomerase complex (ATP-hydrolyzing) GO:0009330
Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity.
|
1 | O67137 (/IPI) |
