The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Histidine kinase-like ATPase, C-terminal domain
".
FunFam 18: Two-component sensor kinase EnvZ
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Phosphorelay sensor kinase activity GO:0000155
Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
|
96 |
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
(86 more) |
|
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
|
96 |
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
(86 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
96 |
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
(86 more) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
96 |
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
P0AEJ4 (/IPI)
(86 more) |
|
Phosphorelay sensor kinase activity GO:0000155
Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
|
6 | Q9KNL9 (/ISS) Q9KNL9 (/ISS) Q9KNL9 (/ISS) Q9KNL9 (/ISS) Q9KNL9 (/ISS) Q9KNL9 (/ISS) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
|
96 |
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
(86 more) |
|
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
|
96 |
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
(86 more) |
|
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
|
96 |
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
(86 more) |
|
Signal transduction by protein phosphorylation GO:0023014
A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate.
|
96 |
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
(86 more) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
96 |
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
(86 more) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
96 |
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
(86 more) |
|
Regulation of response to osmotic stress GO:0047484
Any process that modulates the rate or extent of the response to osmotic stress.
|
96 |
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
P0AEJ4 (/IMP)
(86 more) |
|
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
|
6 | Q9KNL9 (/ISS) Q9KNL9 (/ISS) Q9KNL9 (/ISS) Q9KNL9 (/ISS) Q9KNL9 (/ISS) Q9KNL9 (/ISS) |
|
Osmosensory signaling via phosphorelay pathway GO:0007234
A series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system.
|
6 | Q9KNL9 (/ISS) Q9KNL9 (/ISS) Q9KNL9 (/ISS) Q9KNL9 (/ISS) Q9KNL9 (/ISS) Q9KNL9 (/ISS) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
96 |
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
(86 more) |
|
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
96 |
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
P0AEJ4 (/IDA)
(86 more) |
