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CATH Superfamily 3.30.56.70

N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: tRNA (guanine(26)-N(2))-dimethyltransferase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA (guanine(26)-N(2))-dimethyltransferase. [EC: 2.1.1.216]
2 S-adenosyl-L-methionine + guanine(26) in tRNA = 2 S-adenosyl-L- homocysteine + N(2)-dimethylguanine(26) in tRNA.
  • The enzyme dissociates from its tRNA substrate between the two consecutive methylation reactions.
  • In contrast to EC 2.1.1.215, this enzyme does not catalyze the methylation of guanine(27) in tRNA.
  • Formerly EC 2.1.1.32.
 15 A0A024R7I5 A0A024R7I5 A0A178VEZ9 A0A178VEZ9 P15565 Q23270 Q3TX08 Q58356 Q5JIB3 Q9NXH9
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