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CATH Superfamily 3.30.559.30

Nonribosomal peptide synthetase, condensation domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nonribosomal peptide synthetase, condensation domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: Phthiocerol/phthiodiolone dimycocerosyl transferas...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase. [EC: 2.3.1.282]
(1) 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol = a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase]. (2) 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone = a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase]. (3) 2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol = a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase].
  • The enzyme, present in certain pathogenic species of mycobacteria, catalyzes the transfer of mycocerosic acids to the two hydroxyl groups at the common lipid core of phthiocerol, phthiodiolone, and phenolphthiocerol, forming dimycocerosate esters.
  • The fatty acid precursors of mycocerosic acids are activated by EC 6.2.1.49, which loads them onto EC 2.3.1.111.
  • That enzyme extends the precursors to form mycocerosic acids that remain attached until transferred by EC 2.3.1.282.
 110 A0A045JFL8 A0A045JFL8 A0A045JFL8 A0A045JFL8 A0A045JFL8 A0A045JFL8 A0A045JFL8 A0A045JFL8 A0A045JFL8 A0A045JFL8
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