The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Fructose-1,6-Bisphosphatase, subunit A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Fructose-1,6-bisphosphatase isozyme 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
AMP binding GO:0016208
Interacting selectively and non-covalently with AMP, adenosine monophosphate.
11 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) P19112 (/ISS) Q3SZB7 (/ISS)
(1 more)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
11 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) P19112 (/ISS) Q3SZB7 (/ISS)
(1 more)
Monosaccharide binding GO:0048029
Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H
11 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) P09467 (/ISS) Q3SZB7 (/ISS)
(1 more)
Fructose 1,6-bisphosphate 1-phosphatase activity GO:0042132
Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.
10 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) Q3SZB7 (/ISS) Q9QXD6 (/ISS)
Fructose 1,6-bisphosphate 1-phosphatase activity GO:0042132
Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.
7 A0A060XAF0 (/IDA) A0A060Y8H0 (/IDA) A0A060Y8H0 (/IDA) P00637 (/IDA) P09467 (/IDA) P19112 (/IDA) Q9Z1N1 (/IDA)
Fructose 1,6-bisphosphate 1-phosphatase activity GO:0042132
Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.
3 P70695 (/ISO) P70695 (/ISO) Q9QXD6 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 P70695 (/ISO) P70695 (/ISO) Q9QXD6 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O00757 (/IPI) P09467 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 O00757 (/IPI) P09467 (/IPI)
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
1 P09467 (/IMP)
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
1 Q9QXD6 (/ISO)
AMP binding GO:0016208
Interacting selectively and non-covalently with AMP, adenosine monophosphate.
1 P09467 (/IDA)
AMP binding GO:0016208
Interacting selectively and non-covalently with AMP, adenosine monophosphate.
1 Q9QXD6 (/ISO)
Fructose 1,6-bisphosphate 1-phosphatase activity GO:0042132
Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.
1 P09467 (/IMP)
Fructose 1,6-bisphosphate 1-phosphatase activity GO:0042132
Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.
1 P19112 (/TAS)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
1 P09467 (/IMP)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
1 Q9QXD6 (/ISO)
Monosaccharide binding GO:0048029
Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H
1 P19112 (/IDA)
Monosaccharide binding GO:0048029
Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H
1 Q9QXD6 (/ISO)

There are 42 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fructose 6-phosphate metabolic process GO:0006002
The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism.
11 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) P19112 (/ISS) Q3SZB7 (/ISS)
(1 more)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
11 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) P09467 (/ISS) Q3SZB7 (/ISS)
(1 more)
Regulation of gluconeogenesis GO:0006111
Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
11 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) P19112 (/ISS) Q3SZB7 (/ISS)
(1 more)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
11 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) P19112 (/ISS) Q3SZB7 (/ISS)
(1 more)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
11 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) P19112 (/ISS) Q3SZB7 (/ISS)
(1 more)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
11 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) P19112 (/ISS) Q3SZB7 (/ISS)
(1 more)
Negative regulation of glycolytic process GO:0045820
Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
11 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) P19112 (/ISS) Q3SZB7 (/ISS)
(1 more)
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
11 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) P19112 (/ISS) Q3SZB7 (/ISS)
(1 more)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
11 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) P19112 (/ISS) Q3SZB7 (/ISS)
(1 more)
Cellular response to magnesium ion GO:0071286
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
11 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) P19112 (/ISS) Q3SZB7 (/ISS)
(1 more)
Fructose 6-phosphate metabolic process GO:0006002
The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism.
3 P00637 (/IDA) P09467 (/IDA) P19112 (/IDA)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
3 P70695 (/ISO) P70695 (/ISO) Q9QXD6 (/ISO)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
3 A0A060XAF0 (/IDA) A0A060Y8H0 (/IDA) A0A060Y8H0 (/IDA)
Fructose metabolic process GO:0006000
The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
2 O00757 (/TAS) P09467 (/TAS)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
2 P19112 (/IDA) Q9Z1N1 (/IDA)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
2 O00757 (/TAS) P09467 (/TAS)
Cellular response to estrogen stimulus GO:0071391
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
2 F8W455 (/IDA) Q7T337 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P09467 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9QXD6 (/ISO)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
1 P19112 (/IDA)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
1 Q9QXD6 (/ISO)
Fructose 6-phosphate metabolic process GO:0006002
The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism.
1 Q9QXD6 (/ISO)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
1 P09467 (/IMP)
Regulation of gluconeogenesis GO:0006111
Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
1 P09467 (/IMP)
Regulation of gluconeogenesis GO:0006111
Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
1 Q9QXD6 (/ISO)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
1 P09467 (/IDA)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
1 P09467 (/IMP)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
1 Q9QXD6 (/ISO)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 P09467 (/IDA)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 Q9QXD6 (/ISO)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P19112 (/IEP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P09467 (/IDA)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q9QXD6 (/ISO)
Negative regulation of glycolytic process GO:0045820
Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
1 P09467 (/IDA)
Negative regulation of glycolytic process GO:0045820
Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
1 P09467 (/IMP)
Negative regulation of glycolytic process GO:0045820
Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
1 Q9QXD6 (/ISO)
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
1 P09467 (/IDA)
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
1 Q9QXD6 (/ISO)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 P09467 (/IDA)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 Q9QXD6 (/ISO)
Cellular response to magnesium ion GO:0071286
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
1 P09467 (/IDA)
Cellular response to magnesium ion GO:0071286
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
1 Q9QXD6 (/ISO)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
11 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) P19112 (/ISS) Q3SZB7 (/ISS)
(1 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 E2RAN6 (/ISS) F6YGC3 (/ISS) F7DT76 (/ISS) F7EJG8 (/ISS) P00636 (/ISS) P00636 (/ISS) P00637 (/ISS) P09199 (/ISS) P09467 (/ISS) Q3SZB7 (/ISS)
(1 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P70695 (/ISO) P70695 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O00757 (/TAS) P09467 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P70695 (/ISO) P70695 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 O00757 (/HDA) P09467 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P09467 (/IMP)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9QXD6 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O00757 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P09467 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9QXD6 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P19112 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9QXD6 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O00757 (/IDA)
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