The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Phosphatidylinositol transfer protein alpha isofor...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphatidylcholine transporter activity GO:0008525
Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
14 E7EZR3 (/IDA) F1QRW4 (/IDA) P16446 (/IDA) P48739 (/IDA) P48739 (/IDA) P48739 (/IDA) P48739 (/IDA) P48739 (/IDA) P53812 (/IDA) Q00169 (/IDA)
(4 more)
Phosphatidylinositol transfer activity GO:0008526
Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
14 E7EZR3 (/IDA) F1QRW4 (/IDA) P16446 (/IDA) P48739 (/IDA) P48739 (/IDA) P48739 (/IDA) P48739 (/IDA) P48739 (/IDA) P53812 (/IDA) Q00169 (/IDA)
(4 more)
Phosphatidylcholine binding GO:0031210
Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline.
10 P16446 (/IDA) P48739 (/IDA) P48739 (/IDA) P48739 (/IDA) P48739 (/IDA) P48739 (/IDA) P53812 (/IDA) Q00169 (/IDA) Q00169 (/IDA) Q00169 (/IDA)
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
10 P16446 (/IDA) P48739 (/IDA) P48739 (/IDA) P48739 (/IDA) P48739 (/IDA) P48739 (/IDA) P53812 (/IDA) Q00169 (/IDA) Q00169 (/IDA) Q00169 (/IDA)
Phosphatidylinositol transfer activity GO:0008526
Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
4 P16446 (/TAS) Q00169 (/TAS) Q00169 (/TAS) Q00169 (/TAS)
Phosphatidylcholine transporter activity GO:0008525
Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
3 P53810 (/ISO) P53810 (/ISO) P53811 (/ISO)
Phosphatidylcholine transporter activity GO:0008525
Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
3 Q00169 (/TAS) Q00169 (/TAS) Q00169 (/TAS)
Phosphatidylinositol transfer activity GO:0008526
Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
3 P53810 (/ISO) P53810 (/ISO) P53811 (/ISO)
Phosphatidylcholine binding GO:0031210
Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline.
3 P53810 (/ISO) P53810 (/ISO) P53811 (/ISO)
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
3 P53810 (/ISO) P53810 (/ISO) P53811 (/ISO)
Phosphatidylglycerol binding GO:1901611
Interacting selectively and non-covalently with phosphatidylglycerol.
3 Q00169 (/TAS) Q00169 (/TAS) Q00169 (/TAS)
Fatty-acyl-CoA binding GO:0000062
Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
2 P53810 (/ISO) P53810 (/ISO)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
2 P53810 (/ISO) P53810 (/ISO)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
2 P53810 (/ISS) P53810 (/ISS)
Stearic acid binding GO:0070540
Interacting selectively and non-covalently with stearic acid, the 18-carbon saturated fatty acid octadecanoic acid.
2 P53810 (/ISO) P53810 (/ISO)
Fatty-acyl-CoA binding GO:0000062
Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
1 P16446 (/IDA)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
1 P16446 (/IDA)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
1 P53811 (/ISA)
Phosphatidylinositol transfer activity GO:0008526
Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
1 P53812 (/IMP)
Stearic acid binding GO:0070540
Interacting selectively and non-covalently with stearic acid, the 18-carbon saturated fatty acid octadecanoic acid.
1 P16446 (/IDA)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phospholipid transport GO:0015914
The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
10 P16446 (/IDA) P48739 (/IDA) P48739 (/IDA) P48739 (/IDA) P48739 (/IDA) P48739 (/IDA) P53812 (/IDA) Q00169 (/IDA) Q00169 (/IDA) Q00169 (/IDA)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
8 P48739 (/NAS) P48739 (/NAS) P48739 (/NAS) P48739 (/NAS) P48739 (/NAS) Q00169 (/NAS) Q00169 (/NAS) Q00169 (/NAS)
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890
The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.
5 P48739 (/TAS) P48739 (/TAS) P48739 (/TAS) P48739 (/TAS) P48739 (/TAS)
Nucleus organization GO:0006997
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
5 P48739 (/TAS) P48739 (/TAS) P48739 (/TAS) P48739 (/TAS) P48739 (/TAS)
Phospholipid transport GO:0015914
The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
5 P48739 (/TAS) P48739 (/TAS) P48739 (/TAS) P48739 (/TAS) P48739 (/TAS)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
3 P53810 (/IMP) P53810 (/IMP) Q803U3 (/IMP)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
3 Q00169 (/TAS) Q00169 (/TAS) Q00169 (/TAS)
Phospholipid transport GO:0015914
The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
3 P53810 (/ISO) P53810 (/ISO) P53811 (/ISO)
Interleukin-12-mediated signaling pathway GO:0035722
A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 Q00169 (/TAS) Q00169 (/TAS) Q00169 (/TAS)
Photoreceptor cell outer segment organization GO:0035845
A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials.
3 E7EZR3 (/IMP) F1QRW4 (/IMP) Q7ZUU3 (/IMP)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 P53811 (/IMP)
Phospholipid transport GO:0015914
The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
1 P16446 (/IMP)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
1 Q803U3 (/IMP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
5 P48739 (/TAS) P48739 (/TAS) P48739 (/TAS) P48739 (/TAS) P48739 (/TAS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
5 P48739 (/TAS) P48739 (/TAS) P48739 (/TAS) P48739 (/TAS) P48739 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P53810 (/TAS) P53810 (/TAS) Q00169 (/TAS) Q00169 (/TAS) Q00169 (/TAS)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
4 E7EZR3 (/IDA) F1QRW4 (/IDA) Q7ZUU3 (/IDA) Q802Z3 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 Q00169 (/HDA) Q00169 (/HDA) Q00169 (/HDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P53810 (/ISS) P53810 (/ISS)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
2 P53810 (/HDA) P53810 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q803U3 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q802Z3 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q803U3 (/IDA)
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