The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules.

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.

A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

The process of protecting a cell from natural killer cell mediated cytotoxicity.

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules.

Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.

Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.

The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.

The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules.

Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.

The process in which one or more ubiquitin groups are added to a protein.

The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.

A process involving any mechanism for tolerance induction in T cells.

Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen.

Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.

Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production.

Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production.

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.

The process of protecting a cell from natural killer cell mediated cytotoxicity.

Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.

Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.

The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.

Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.

Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.

The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.

Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue.

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.

Any process that activates or increases the frequency, rate, or extent of tolerance induction.

Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction.

Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response.

Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.

An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.

The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

Any process that activates or increases the frequency, rate or extent of protein binding.

Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.

Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.

Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.

The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Any process that stops, prevents or reduces the rate or extent of T cell proliferation.

Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.

Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells.

Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.

Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.

Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.

Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.

Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.

Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.

The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.

A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.

Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.

Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor.

Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor.

Any process that stops, prevents or reduces the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I.

Any process that activates or increases the frequency, rate or extent of ferrous iron binding.

Any process that activates or increases the frequency, rate or extent of transferrin receptor binding.

Any process that modulates the frequency, rate or extent of protein localization to the cell surface.

Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity.

Any process that activates or increases the frequency, rate or extent of signaling receptor activity.

Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process.

Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation.

Any process that activates or increases the frequency, rate or extent of cellular senescence.

Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation.

Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell activation.

Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation.

The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.

Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity.

A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.

Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.

Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.

An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).

The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.

Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue.

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules.

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.

Tolerance induction of natural killer cells.

Any process that activates or increases the frequency, rate, or extent of tolerance induction.

Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction.

Any process that modulates the frequency, rate, or extent of T cell anergy.

Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity.

Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity.

Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.

Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.

Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production.

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response.

A defense response that is mediated by cells.

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.

An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.

Any process that modulates the frequency, rate, or extent of interleukin-12 production.

Any process that modulates the frequency, rate, or extent of interleukin-6 production.

Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.

Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.

Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.

Any process that activates or increases the frequency, rate, or extent of TRAIL production.

Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.

Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation.

The increase in size or mass of an entire multicellular organism, as opposed to cell growth.

The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

Any process that stops, prevents or reduces the rate or extent of T cell proliferation.

Any process that stops, prevents, or reduces the rate of natural killer cell degranulation.

Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation.

Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells.

Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.

Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism.

Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.

A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.

Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell.

The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.

Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.

The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.

A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.

Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.

Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process.

Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation.

Any process that activates or increases the frequency, rate or extent of memory T cell activation.

Any process that activates or increases the frequency, rate or extent of cellular senescence.

Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell activation.

Any process that modulates the frequency, rate or extent of dendritic cell differentiation.

Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation.

The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.

Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity.

An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.

Tolerance induction of natural killer cells.

Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity.

Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity.

Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.

Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.

Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.

An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.

Attachment of the blastocyst to the uterine lining.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions.

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

Any process that activates or increases the frequency, rate or extent of protein binding.

The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.

Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.

Any process that activates or increases the frequency, rate, or extent of TRAIL production.

Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.

Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation.

Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.

The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.

Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.

Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.

Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.

Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell.

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.

Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.

Any process involved in the maintenance of the distribution of iron stores within tissues and organs of a multicellular organism.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.

Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.

The regrowth of lost or destroyed liver.

Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor.

Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor.

Any process that stops, prevents or reduces the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I.

Any process that activates or increases the frequency, rate or extent of ferrous iron binding.

Any process that activates or increases the frequency, rate or extent of transferrin receptor binding.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion.

Any process that modulates the frequency, rate or extent of protein localization to the cell surface.

Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity.

Any process that activates or increases the frequency, rate or extent of signaling receptor activity.

Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation.

The lipid bilayer surrounding a phagocytic vesicle.

The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane.

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.

The lipid bilayer surrounding an early endosome.

The lipid bilayer surrounding a recycling endosome.

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.

The external part of the cell wall and/or plasma membrane.

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

The external part of the cell wall and/or plasma membrane.

A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

The external part of the cell wall and/or plasma membrane.

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

The middle Golgi cisterna (or cisternae).

A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.

An endoplasmic reticulum part at which COPII-coated vesicles are produced.

A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

The lipid bilayer surrounding a secretory granule.

The lipid bilayer surrounding the endoplasmic reticulum.

A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.

A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

A vesicle found in the cytoplasm of a cell.

The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network.

The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.

Cytoplasm situated near, or occurring around, the nucleus.

An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

The middle Golgi cisterna (or cisternae).

The external part of the cell wall and/or plasma membrane.

The lipid bilayer surrounding an early endosome.

A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.

The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network.

A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.

An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.

An endoplasmic reticulum part at which COPII-coated vesicles are produced.

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.

The external part of the cell wall and/or plasma membrane.

A vesicle found in the cytoplasm of a cell.

The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.

Cytoplasm situated near, or occurring around, the nucleus.

An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells.

An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells.

A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.