The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Erythroid Transcription Factor GATA-1, subunit A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Nitrogen regulatory AreA, N-terminal

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
11 G5EB20 (/IDA) P17429 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA)
(1 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
9 P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P42944 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
4 P18494 (/IMP) Q5A432 (/IMP) Q5AP95 (/IMP) Q9HEV3 (/IMP)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
3 P18494 (/IDA) Q10134 (/IDA) Q10280 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P17429 (/IPI) P18494 (/IPI) Q10134 (/IPI)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 Q10134 (/IDA) Q10280 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 P18494 (/HDA) P42944 (/HDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2 P17429 (/IDA) Q5AP95 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P42944 (/IMP)
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q10280 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q10134 (/IMP)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P43574 (/IMP)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q10280 (/IPI)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 Q10134 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P18494 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 A0A1D8PNX9 (/ISA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 A0A1D8PNX9 (/ISS)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
1 Q10134 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 P43574 (/IGI)
Iron-sulfur cluster binding GO:0051536
Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms.
1 Q10134 (/IDA)

There are 38 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
12 P18494 (/IMP) P26343 (/IMP) P26343 (/IMP) P26343 (/IMP) P26343 (/IMP) P26343 (/IMP) P26343 (/IMP) P26343 (/IMP) P26343 (/IMP) P42944 (/IMP)
(2 more)
Nitrogen catabolite repression of transcription GO:0090295
A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.
9 P26343 (/IMP) P26343 (/IMP) P26343 (/IMP) P26343 (/IMP) P26343 (/IMP) P26343 (/IMP) P26343 (/IMP) P26343 (/IMP) P42944 (/IMP)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
7 G5EB20 (/IMP) Q10134 (/IMP) Q4WV91 (/IMP) Q4WV91 (/IMP) Q4WV91 (/IMP) Q4WV91 (/IMP) Q5AP95 (/IMP)
Regulation of nitrogen utilization GO:0006808
Any process that modulates the frequency, rate or extent of nitrogen utilization.
5 A0A1D8PNX9 (/IMP) P17429 (/IMP) Q4WCP6 (/IMP) Q4WCP6 (/IMP) Q5A432 (/IMP)
Negative regulation of iron ion transport GO:0034757
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
5 G5EB20 (/IMP) Q4WV91 (/IMP) Q4WV91 (/IMP) Q4WV91 (/IMP) Q4WV91 (/IMP)
Cellular response to iron ion starvation GO:0010106
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions.
4 Q4WV91 (/IEP) Q4WV91 (/IEP) Q4WV91 (/IEP) Q4WV91 (/IEP)
Nitrogen catabolite activation of transcription from RNA polymerase II promoter GO:0001080
A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.
3 P18494 (/IMP) P43574 (/IMP) Q6FWW9 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P18494 (/IMP) Q5A432 (/IMP) Q5AP95 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
2 A0A1D8PNX9 (/IMP) Q5A432 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
2 A0A1D8PNX9 (/IMP) Q5A201 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 A0A1D8PNX9 (/IMP) Q5A201 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation GO:0036278
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a deprivation of nitrogen.
2 P18494 (/IMP) P43574 (/IMP)
Cellular response to copper ion GO:0071280
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
2 Q5A201 (/IMP) Q5AP95 (/IMP)
Regulation of arginine metabolic process GO:0000821
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
1 P17429 (/IMP)
Nitrogen catabolite activation of transcription from RNA polymerase II promoter GO:0001080
A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.
1 P43574 (/IGI)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 P17429 (/IDA)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 P17429 (/IMP)
Regulation of nitrogen utilization GO:0006808
Any process that modulates the frequency, rate or extent of nitrogen utilization.
1 A0A1D8PNX9 (/ISS)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
1 A0A1D8PNX9 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P17429 (/IMP)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 P43574 (/IMP)
Regulation of cellular amide catabolic process GO:0034251
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.
1 P17429 (/IMP)
Negative regulation of transcription from RNA polymerase II promoter in response to iron GO:0034396
Any process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus.
1 Q10134 (/IMP)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
1 Q5A201 (/IMP)
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
1 A0A1D8PNX9 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 A0A1D8PNX9 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 A0A1D8PNX9 (/ISS)
Maintenance of protein location in nucleus GO:0051457
Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus.
1 P42944 (/IPI)
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
1 Q5AP95 (/IMP)
Cellular response to lithium ion GO:0071285
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
1 Q5A201 (/IMP)
Nitrogen catabolite activation of transcription GO:0090294
A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.
1 P43574 (/IGI)
Nitrogen catabolite activation of transcription GO:0090294
A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.
1 P43574 (/IMP)
Nitrogen catabolite repression of transcription GO:0090295
A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.
1 P42944 (/IGI)
Negative regulation of ferrichrome biosynthetic process in response to iron GO:0097739
Any process that stops, prevents or reduces the rate of ferrichrome biosynthetic process in response to an iron stimulus.
1 Q10134 (/IC)
Negative regulation of ferrichrome biosynthetic process in response to iron GO:0097739
Any process that stops, prevents or reduces the rate of ferrichrome biosynthetic process in response to an iron stimulus.
1 Q10134 (/IMP)
Negative regulation of cellular response to iron ion starvation GO:1901967
Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to iron ion starvation.
1 Q10134 (/IMP)
Negative regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter GO:1902625
A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of induction of conjugation with cellular fusion.
1 Q10280 (/IMP)
Regulation of protein localization by the Cvt pathway GO:2001159
Any process that modulates the frequency, rate or extent of protein localization by the Cvt pathway.
1 P18494 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
14 P17429 (/IDA) P18494 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA) P26343 (/IDA)
(4 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P43574 (/IDA) Q10280 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P18494 (/IDA) Q10280 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q10134 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q10134 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P43574 (/IPI)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q10280 (/HDA)
Cell division site GO:0032153
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
1 Q10280 (/HDA)
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