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CATH Superfamily 3.30.499.10

Aconitase, domain 3

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aconitase, domain 3
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26: Aconitate hydratase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aconitate hydratase. [EC: 4.2.1.3]
Citrate = isocitrate.
  • Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate.
  • The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate.
  • Cis-aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3- tricarboxylate.
  • Formerly EC 4.2.1.4.
 5 A0A2A6N7A0 A0A2A6N7A0 P70920 P70920 Q59938
2-methylisocitrate dehydratase. [EC: 4.2.1.99]
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3- tricarboxylate + H(2)O.
  • The enzyme from the fungus Yarrowia lipolytica does not act on isocitrate.
 5 A0A2A6N7A0 A0A2A6N7A0 P70920 P70920 Q59938