The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"ATP-grasp fold, B domain
".
FunFam 9: tubulin polyglutamylase TTLL5 isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
|
5 | A8CVX7 (/ISS) Q14679 (/ISS) Q14679 (/ISS) Q23MT7 (/ISS) Q8N841 (/ISS) |
Protein-glycine ligase activity GO:0070735
Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target protein.
|
5 | A1ZBN5 (/ISS) Q8IPB2 (/ISS) Q9VB58 (/ISS) Q9VBX5 (/ISS) Q9VQV6 (/ISS) |
Tubulin-glutamic acid ligase activity GO:0070740
Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule.
|
5 | A4Q9F0 (/IDA) F7E540 (/IDA) Q23MT7 (/IDA) Q6ZT98 (/IDA) Q9VBX5 (/IDA) |
Protein-glutamic acid ligase activity GO:0070739
Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein.
|
4 | A8CVX7 (/ISS) Q14679 (/ISS) Q14679 (/ISS) Q8N841 (/ISS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | A4Q9E8 (/IPI) Q80UG8 (/IPI) Q8N841 (/IPI) |
Tubulin-tyrosine ligase activity GO:0004835
Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.
|
2 | Q384Y9 (/ISM) Q384Y9 (/ISM) |
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
|
2 | A4Q9E8 (/IDA) Q80UG8 (/IDA) |
Protein-glutamic acid ligase activity GO:0070739
Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein.
|
2 | A4Q9E8 (/IDA) Q80UG8 (/IDA) |
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
|
1 | Q6ZT98 (/IDA) |
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
|
1 | A4Q9F0 (/ISO) |
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
|
1 | A4Q9F0 (/ISS) |
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
|
1 | Q6ZT98 (/IDA) |
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
|
1 | A4Q9F0 (/ISO) |
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
|
1 | A4Q9F0 (/ISS) |
Tubulin-glutamic acid ligase activity GO:0070740
Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule.
|
1 | A8CVX7 (/IMP) |
Tubulin-glutamic acid ligase activity GO:0070740
Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule.
|
1 | A4Q9F0 (/ISO) |
There are 24 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein polyglutamylation GO:0018095
The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid.
|
6 | A4Q9E8 (/IDA) A4Q9F0 (/IDA) F7E540 (/IDA) Q23MT7 (/IDA) Q6ZT98 (/IDA) Q80UG8 (/IDA) |
Protein polyglutamylation GO:0018095
The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid.
|
6 | A6NNM8 (/TAS) Q14679 (/TAS) Q14679 (/TAS) Q6EMB2 (/TAS) Q6ZT98 (/TAS) Q8N841 (/TAS) |
Protein polyglycylation GO:0018094
The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid.
|
5 | A1ZBN5 (/ISS) Q8IPB2 (/ISS) Q9VB58 (/ISS) Q9VBX5 (/ISS) Q9VQV6 (/ISS) |
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
|
5 | M9NCT3 (/IMP) M9NEE5 (/IMP) Q8IGW4 (/IMP) Q8IPB2 (/IMP) Q9VKL9 (/IMP) |
Protein polyglutamylation GO:0018095
The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid.
|
4 | A8CVX7 (/ISS) Q14679 (/ISS) Q14679 (/ISS) Q8N841 (/ISS) |
Protein polyglutamylation GO:0018095
The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid.
|
3 | A4Q9F0 (/IMP) A8CVX7 (/IMP) Q8CHB8 (/IMP) |
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
|
2 | Q384Y9 (/ISM) Q384Y9 (/ISM) |
Peptidyl-glutamic acid modification GO:0018200
The modification of peptidyl-glutamic acid.
|
2 | Q14679 (/ISS) Q14679 (/ISS) |
Microtubule bundle formation GO:0001578
A process that results in a parallel arrangement of microtubules.
|
1 | A4Q9E8 (/IGI) |
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
|
1 | A8CVX7 (/IGI) |
Positive regulation of cilium movement GO:0003353
Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
|
1 | A4Q9E8 (/IMP) |
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
1 | Q8CHB8 (/IMP) |
Sperm axoneme assembly GO:0007288
The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.
|
1 | Q8CHB8 (/IMP) |
Fertilization GO:0009566
The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
|
1 | Q8CHB8 (/IMP) |
Protein polyglutamylation GO:0018095
The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid.
|
1 | A4Q9F0 (/ISO) |
Peptidyl-glutamic acid modification GO:0018200
The modification of peptidyl-glutamic acid.
|
1 | Q80UG8 (/IDA) |
C-terminal protein amino acid modification GO:0018410
The alteration of the C-terminal amino acid residue in a protein.
|
1 | Q9VBX5 (/IDA) |
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
|
1 | Q8CHB8 (/IMP) |
Axoneme assembly GO:0035082
The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
|
1 | A8CVX7 (/IGI) |
Axoneme assembly GO:0035082
The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
|
1 | A8CVX7 (/IMP) |
Microtubule severing GO:0051013
The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends
|
1 | A4Q9E8 (/IDA) |
Microtubule severing GO:0051013
The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends
|
1 | A4Q9E8 (/IGI) |
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
|
1 | Q6EMB2 (/IMP) |
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
|
1 | Q8CHB8 (/ISO) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
6 | A6NNM8 (/TAS) Q14679 (/TAS) Q14679 (/TAS) Q6EMB2 (/TAS) Q6ZT98 (/TAS) Q8N841 (/TAS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q384Y9 (/IDA) Q384Y9 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | G3V2J9 (/IDA) Q6EMB2 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | G3V2J9 (/IDA) Q6EMB2 (/IDA) |
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
|
2 | A8CVX7 (/IDA) Q8CHB8 (/IDA) |
Ciliary basal body GO:0036064
A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
|
2 | A4Q9E8 (/ISS) A8CVX7 (/ISS) |
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
1 | Q6EMB2 (/IDA) |
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
1 | Q8CHB8 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8CHB8 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8CHB8 (/ISO) |
Ciliary basal body GO:0036064
A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
|
1 | Q8N841 (/IDA) |
Ciliary basal body GO:0036064
A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
|
1 | A4Q9E8 (/ISO) |