The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"ATP-grasp fold, B domain
".
FunFam 49: tubulin--tyrosine ligase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Tubulin-tyrosine ligase activity GO:0004835
Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.
|
5 | P38585 (/IMP) Q8NG68 (/IMP) Q8NG68 (/IMP) Q8NG68 (/IMP) Q8NG68 (/IMP) |
|
Tubulin-tyrosine ligase activity GO:0004835
Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.
|
1 | P38584 (/EXP) |
|
Tubulin-tyrosine ligase activity GO:0004835
Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.
|
1 | Q9QXJ0 (/IDA) |
|
Tubulin-tyrosine ligase activity GO:0004835
Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.
|
1 | P38585 (/ISO) |
There are 8 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
C-terminal protein-tyrosinylation GO:0018166
The ATP-dependent addition of a tyrosine residue to the C-terminus of a protein; typically the addition of tyrosine to the C-terminus of detyrosinated alpha-tubulin by the enzyme tubulin-tyrosine ligase.
|
4 | Q8NG68 (/IMP) Q8NG68 (/IMP) Q8NG68 (/IMP) Q8NG68 (/IMP) |
|
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
|
4 | Q8NG68 (/IMP) Q8NG68 (/IMP) Q8NG68 (/IMP) Q8NG68 (/IMP) |
|
Regulation of metaphase plate congression GO:0090235
Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle.
|
4 | Q8NG68 (/IMP) Q8NG68 (/IMP) Q8NG68 (/IMP) Q8NG68 (/IMP) |
|
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
|
1 | P38585 (/IMP) |
|
C-terminal protein-tyrosinylation GO:0018166
The ATP-dependent addition of a tyrosine residue to the C-terminus of a protein; typically the addition of tyrosine to the C-terminus of detyrosinated alpha-tubulin by the enzyme tubulin-tyrosine ligase.
|
1 | P38585 (/ISO) |
|
Regulation of axon extension GO:0030516
Any process that modulates the rate, direction or extent of axon extension.
|
1 | P38585 (/IMP) |
|
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
|
1 | P38585 (/ISO) |
|
Regulation of metaphase plate congression GO:0090235
Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle.
|
1 | P38585 (/ISO) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
4 | Q8NG68 (/IMP) Q8NG68 (/IMP) Q8NG68 (/IMP) Q8NG68 (/IMP) |
|
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
1 | P38585 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P38584 (/TAS) |
|
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
|
1 | P38585 (/IC) |
