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CATH Superfamily 3.30.470.20

ATP-grasp fold, B domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
ATP-grasp fold, B domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 40: Carnosine synthase 1

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Carnosine synthase. [EC: 6.3.2.11]
ATP + L-histidine + beta-alanine = ADP + phosphate + carnosine.
  • This enzyme was thought to form AMP, but studies with highly purified enzyme proved that it forms ADP.
  • Carnosine is a dipeptide that is present at high concentrations in skeletal muscle and the olfactory bulb of vertebrates.
  • It is also found in the skeletal muscle of some invertebrates.
  • The enzyme can also catalyze the formation of homocarnosine from 4-aminobutyrate and L-histidine, with much lower activity.
 3 A5YM72 D3KCC4 Q6ZPS2
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