The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
ATP-grasp fold, B domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 28: Methylcrotonoyl-CoA carboxylase subunit alpha, mit...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Propionyl-CoA carboxylase activity GO:0004658
Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.
6 Q2GGY0 (/ISS) Q2GKY0 (/ISS) Q2GKY0 (/ISS) Q2GKY0 (/ISS) Q2GKY0 (/ISS) Q5LUF3 (/ISS)
Methylcrotonoyl-CoA carboxylase activity GO:0004485
Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate.
5 Q42523 (/IDA) Q42777 (/IDA) Q5B440 (/IDA) Q5B440 (/IDA) Q9I299 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q5LUF3 (/IPI) Q96RQ3 (/IPI) Q96RQ3 (/IPI) Q9I299 (/IPI)
Methylcrotonoyl-CoA carboxylase activity GO:0004485
Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate.
3 Q5LPR0 (/ISS) Q8I0S9 (/ISS) Q9V9T5 (/ISS)
Acetyl-CoA carboxylase activity GO:0003989
Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
2 Q5B440 (/RCA) Q5B440 (/RCA)
Biotin carboxylase activity GO:0004075
Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein.
2 Q96RQ3 (/NAS) Q96RQ3 (/NAS)
Biotin carboxylase activity GO:0004075
Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein.
2 Q5B440 (/RCA) Q5B440 (/RCA)
Pyruvate carboxylase activity GO:0004736
Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate.
2 Q5B440 (/RCA) Q5B440 (/RCA)
Biotin binding GO:0009374
Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.
2 Q96RQ3 (/NAS) Q96RQ3 (/NAS)
Methylcrotonoyl-CoA carboxylase activity GO:0004485
Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate.
1 Q9I299 (/IMP)
Methylcrotonoyl-CoA carboxylase activity GO:0004485
Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate.
1 Q57YQ4 (/ISA)
Biotin binding GO:0009374
Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.
1 Q57YQ4 (/ISA)
Geranoyl-CoA carboxylase activity GO:0047925
Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H(+) + phosphate.
1 Q9HZV6 (/IDA)
Cobalt ion binding GO:0050897
Interacting selectively and non-covalently with a cobalt (Co) ion.
1 Q42523 (/IDA)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fatty acid catabolic process GO:0009062
The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
5 Q2GGY0 (/ISS) Q2GKY0 (/ISS) Q2GKY0 (/ISS) Q2GKY0 (/ISS) Q2GKY0 (/ISS)
Cellular amino acid catabolic process GO:0009063
The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
5 Q2GGY0 (/ISS) Q2GKY0 (/ISS) Q2GKY0 (/ISS) Q2GKY0 (/ISS) Q2GKY0 (/ISS)
Leucine catabolic process GO:0006552
The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid.
4 Q5B440 (/IMP) Q5B440 (/IMP) Q6T5L7 (/IMP) Q9I299 (/IMP)
Leucine catabolic process GO:0006552
The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid.
3 Q5LPR0 (/ISS) Q96RQ3 (/ISS) Q96RQ3 (/ISS)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
2 Q5B440 (/RCA) Q5B440 (/RCA)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
2 Q5B440 (/RCA) Q5B440 (/RCA)
Leucine metabolic process GO:0006551
The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid.
2 Q8I0S9 (/ISS) Q9V9T5 (/ISS)
Leucine catabolic process GO:0006552
The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid.
2 Q96RQ3 (/NAS) Q96RQ3 (/NAS)
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
2 Q5B440 (/RCA) Q5B440 (/RCA)
Biotin metabolic process GO:0006768
The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.
2 Q96RQ3 (/NAS) Q96RQ3 (/NAS)
Biotin metabolic process GO:0006768
The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.
2 Q96RQ3 (/TAS) Q96RQ3 (/TAS)
Branched-chain amino acid catabolic process GO:0009083
The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
2 Q96RQ3 (/TAS) Q96RQ3 (/TAS)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 Q96RQ3 (/NAS) Q96RQ3 (/NAS)
Leucine catabolic process GO:0006552
The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid.
1 Q42523 (/IDA)
Isoprenoid catabolic process GO:0008300
The chemical reactions and pathways resulting in the breakdown of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
1 Q9I299 (/IMP)
Propionate metabolic process GO:0019541
The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants.
1 Q5LUF3 (/ISS)
Pyrimidine nucleobase biosynthetic process GO:0019856
The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
1 Q57YQ4 (/ISA)
Terpene catabolic process GO:0046247
The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units.
1 Q9HZV6 (/IDA)
Terpene catabolic process GO:0046247
The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units.
1 Q9I299 (/IMP)

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
14 P71538 (/HDA) P71538 (/HDA) P71538 (/HDA) P71538 (/HDA) P71538 (/HDA) P71538 (/HDA) P9WPQ3 (/HDA) P9WPQ3 (/HDA) P9WPQ3 (/HDA) P9WPQ3 (/HDA)
(4 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 A0A0S2Z693 (/IDA) A0A0S2Z693 (/IDA) E9PHF7 (/IDA) Q42523 (/IDA) Q96RQ3 (/IDA) Q96RQ3 (/IDA)
Methylcrotonoyl-CoA carboxylase complex GO:1905202
A protein complex which is capable of methylcrotonoyl-CoA carboxylase activity.
3 Q96RQ3 (/IDA) Q96RQ3 (/IDA) Q9I299 (/IDA)
3-methylcrotonyl-CoA carboxylase complex, mitochondrial GO:0002169
A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA.
2 Q96RQ3 (/NAS) Q96RQ3 (/NAS)
3-methylcrotonyl-CoA carboxylase complex, mitochondrial GO:0002169
A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA.
2 Q96RQ3 (/TAS) Q96RQ3 (/TAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q96RQ3 (/IDA) Q96RQ3 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q8I0S9 (/ISS) Q9V9T5 (/ISS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q96RQ3 (/NAS) Q96RQ3 (/NAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q96RQ3 (/TAS) Q96RQ3 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q96RQ3 (/TAS) Q96RQ3 (/TAS)
Methylcrotonoyl-CoA carboxylase complex GO:1905202
A protein complex which is capable of methylcrotonoyl-CoA carboxylase activity.
2 Q5I0C3 (/ISS) Q99MR8 (/ISS)
3-methylcrotonyl-CoA carboxylase complex, mitochondrial GO:0002169
A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA.
1 Q99MR8 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q57YQ4 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q99MR8 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q57YQ4 (/ISA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q99MR8 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q57YQ4 (/RCA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q99MR8 (/HDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q99MR8 (/ISO)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
1 Q57YQ4 (/IDA)
Cytosolic ribosome GO:0022626
A ribosome located in the cytosol.
1 Q42523 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q553S7 (/HDA)
Methylcrotonoyl-CoA carboxylase complex GO:1905202
A protein complex which is capable of methylcrotonoyl-CoA carboxylase activity.
1 Q99MR8 (/ISO)
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