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CATH Superfamily 3.30.470.160

Inositol polyphosphate kinase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Inositol polyphosphate kinase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Inositol polyphosphate multikinase alpha

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Inositol-polyphosphate multikinase. [EC: 2.7.1.151]
2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
  • This enzyme also phosphorylates Ins(1,4,5)P(3) to Ins(1,3,4,5)P(4), Ins(1,3,4,5)P(4) to Ins(1,3,4,5,6)P(5), and Ins(1,3,4,5,6)P(4) to Ins(PP)P(4), isomer unknown.
  • The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P(4) and Ins(1,2,3,4,6)P(5) at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP(6)), respectively.
  • Yeast produces InsP(6) from Ins(1,4,5)P(3) by the actions of this enzyme and EC 2.7.1.158.
 10 A0A384LG67 A0A384LG67 A0A384LG67 B9DGE0 B9DGE0 B9DGE0 Q9FLT2 Q9LY23 Q9LY23 Q9LY23
Inositol-tetrakisphosphate 5-kinase. [EC: 2.7.1.140]
ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
  • The enzyme from plants and yeast can also use Ins(1,2,3,4,6)P(5) as a substrate.
 10 A0A384LG67 A0A384LG67 A0A384LG67 B9DGE0 B9DGE0 B9DGE0 Q9FLT2 Q9LY23 Q9LY23 Q9LY23
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