The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Inositol polyphosphate kinase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 2: Kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Inositol hexakisphosphate kinase activity GO:0000828
Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown.
17 Q92551 (/IDA) Q92551 (/IDA) Q96PC2 (/IDA) Q96PC2 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA)
(7 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
16 Q92551 (/IPI) Q92551 (/IPI) Q9ESM0 (/IPI) Q9UHH9 (/IPI) Q9UHH9 (/IPI) Q9UHH9 (/IPI) Q9UHH9 (/IPI) Q9UHH9 (/IPI) Q9UHH9 (/IPI) Q9UHH9 (/IPI)
(6 more)
Inositol hexakisphosphate 5-kinase activity GO:0000832
Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.
13 Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA)
(3 more)
Flavonoid binding GO:0097243
Interacting selectively and non-covalently with a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge.
13 Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA)
(3 more)
Inositol hexakisphosphate kinase activity GO:0000828
Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown.
3 Q6PD10 (/ISO) Q80V72 (/ISO) Q8BWD2 (/ISO)
Inositol hexakisphosphate 5-kinase activity GO:0000832
Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.
3 Q80V72 (/ISS) Q95221 (/ISS) Q9R0U1 (/ISS)
Flavonoid binding GO:0097243
Interacting selectively and non-covalently with a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge.
3 Q80V72 (/ISS) Q95221 (/ISS) Q9R0U1 (/ISS)
Inositol hexakisphosphate 6-kinase activity GO:0000831
Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate.
2 Q96PC2 (/IDA) Q96PC2 (/IDA)
Inositol hexakisphosphate 6-kinase activity GO:0000831
Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate.
1 Q8BWD2 (/ISO)
Inositol hexakisphosphate 5-kinase activity GO:0000832
Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.
1 Q80V72 (/ISO)
Flavonoid binding GO:0097243
Interacting selectively and non-covalently with a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge.
1 Q80V72 (/ISO)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Inositol phosphate metabolic process GO:0043647
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
17 Q92551 (/TAS) Q92551 (/TAS) Q96PC2 (/TAS) Q96PC2 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS)
(7 more)
Phosphatidylinositol phosphorylation GO:0046854
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
15 Q92551 (/IDA) Q92551 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA)
(5 more)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
13 Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP)
(3 more)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
13 Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP)
(3 more)
Inositol phosphate metabolic process GO:0043647
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
13 Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA) Q9UHH9 (/IDA)
(3 more)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
13 Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS)
(3 more)
Cellular response to flavonoid GO:1905396
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus.
13 Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP) Q9UHH9 (/IMP)
(3 more)
Inositol phosphate metabolic process GO:0043647
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
3 Q80V72 (/ISS) Q95221 (/ISS) Q9R0U1 (/ISS)
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
3 Q92551 (/ISS) Q92551 (/ISS) Q9ESM0 (/ISS)
Cellular response to flavonoid GO:1905396
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus.
3 Q80V72 (/ISS) Q95221 (/ISS) Q9R0U1 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 Q96PC2 (/IDA) Q96PC2 (/IDA)
Inositol phosphate biosynthetic process GO:0032958
The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
2 Q96PC2 (/IDA) Q96PC2 (/IDA)
Inositol phosphate biosynthetic process GO:0032958
The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
2 Q6PD10 (/ISO) Q8BWD2 (/ISO)
Phosphatidylinositol metabolic process GO:0046488
The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
2 Q96PC2 (/IDA) Q96PC2 (/IDA)
Phosphatidylinositol phosphorylation GO:0046854
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
2 Q6PD10 (/ISO) Q80V72 (/ISO)
Phosphatidylinositol phosphorylation GO:0046854
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.
2 Q6PD10 (/ISS) Q9ESM0 (/ISS)
Inositol metabolic process GO:0006020
The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.
1 Q6PD10 (/ISO)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q8BWD2 (/ISO)
Phosphate ion transport GO:0006817
The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9R0U1 (/IDA)
Phosphate ion transport GO:0006817
The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q80V72 (/ISO)
Signal transduction downstream of smoothened GO:0007227
The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.
1 Q6PBN6 (/IMP)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 Q80V72 (/ISO)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q80V72 (/ISO)
Inositol phosphate metabolic process GO:0043647
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
1 Q80V72 (/ISO)
Positive regulation of smoothened signaling pathway GO:0045880
Any process that activates or increases the frequency, rate or extent of smoothened signaling.
1 Q6PBN6 (/IMP)
Phosphatidylinositol metabolic process GO:0046488
The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
1 Q8BWD2 (/ISO)
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
1 Q6PD10 (/IMP)
Cellular response to flavonoid GO:1905396
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus.
1 Q80V72 (/ISO)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
33 A0A024R2X2 (/IDA) A0A024R2X2 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA)
(23 more)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
30 A0A024R2X2 (/IDA) A0A024R2X2 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA)
(20 more)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
26 B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA) B2RCP4 (/IDA)
(16 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
15 Q92551 (/TAS) Q92551 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS) Q9UHH9 (/TAS)
(5 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 A0A024R2X2 (/IDA) A0A024R2X2 (/IDA) Q92551 (/IDA) Q92551 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q92551 (/TAS) Q92551 (/TAS) Q96PC2 (/TAS) Q96PC2 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q6PD10 (/IDA) Q96PC2 (/IDA) Q96PC2 (/IDA)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
2 Q6PD10 (/ISO) Q80V72 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q6PD10 (/ISO) Q80V72 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8BWD2 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q6PD10 (/ISO)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
1 Q80V72 (/ISO)
CATH-Gene3D is a Global Biodata Core Resource Learn more...