The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Beta Polymerase, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: interleukin enhancer-binding factor 3 isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 23 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
15 A0A0S2Z5K8 (/IPI) Q12906 (/IPI) Q12906 (/IPI) Q96SI9 (/IPI) Q96SI9 (/IPI) Q96SI9 (/IPI) Q96SI9 (/IPI) Q96SI9 (/IPI) Q96SI9 (/IPI) Q96SI9 (/IPI)
(5 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
13 Q12906 (/HDA) Q12906 (/HDA) Q96SI9 (/HDA) Q96SI9 (/HDA) Q96SI9 (/HDA) Q96SI9 (/HDA) Q96SI9 (/HDA) Q96SI9 (/HDA) Q96SI9 (/HDA) Q96SI9 (/HDA)
(3 more)
MRNA 3'-UTR AU-rich region binding GO:0035925
Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
6 Q6DD04 (/ISS) Q6GL57 (/ISS) Q6NXA4 (/ISS) Q91550 (/ISS) Q9JIL3 (/ISS) Q9Z1X4 (/ISS)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
5 Q12906 (/IDA) Q12906 (/IDA) Q2TAV5 (/IDA) Q91550 (/IDA) Q91WM1 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 Q12906 (/IDA) Q12906 (/IDA) Q2TAV5 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q12906 (/NAS) Q12906 (/NAS)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
2 Q6DD04 (/ISS) Q6GL57 (/ISS)
MRNA 3'-UTR AU-rich region binding GO:0035925
Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
2 Q12906 (/IDA) Q12906 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 Q6DD04 (/ISS) Q6GL57 (/ISS)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2 Q2TAV5 (/IDA) Q91550 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2 Q6DD04 (/ISS) Q6GL57 (/ISS)
MRNA 5'-UTR binding GO:0048027
Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule.
2 Q6DD04 (/ISS) Q6GL57 (/ISS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q9Z1X4 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q9Z1X4 (/TAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q9JIL3 (/TAS)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
1 Q9Z1X4 (/ISO)
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
1 Q91WM1 (/IDA)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
1 Q91WM1 (/IDA)
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
1 Q91WM1 (/IDA)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q9JIL3 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q9Z1X4 (/ISO)
MRNA 3'-UTR AU-rich region binding GO:0035925
Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
1 Q9Z1X4 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q91550 (/IDA)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
3 Q12906 (/IDA) Q12906 (/IDA) Q9Z1X4 (/IDA)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
3 Q12906 (/ISS) Q12906 (/ISS) Q9JIL3 (/ISS)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
3 Q12906 (/ISS) Q12906 (/ISS) Q9JIL3 (/ISS)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q2TAV5 (/IDA) Q91550 (/IDA)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q6DD04 (/ISS) Q6GL57 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 Q12906 (/IDA) Q12906 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 Q12906 (/IDA) Q12906 (/IDA)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q91550 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q9Z1X4 (/ISO)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q9JIL3 (/ISS)
Protein methylation GO:0006479
The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
1 Q9JIL3 (/IDA)
Protein methylation GO:0006479
The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
1 Q9Z1X4 (/ISO)
Spermatid development GO:0007286
The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
1 Q91WM1 (/IMP)
Mechanosensory behavior GO:0007638
Behavior that is dependent upon the sensation of a mechanical stimulus.
1 Q91WM1 (/IMP)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 Q9Z1X4 (/IMP)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
1 Q9Z1X4 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9Z1X4 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9Z1X4 (/ISO)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
16 Q12906 (/IDA) Q12906 (/IDA) Q2TAV5 (/IDA) Q91550 (/IDA) Q96SI9 (/IDA) Q96SI9 (/IDA) Q96SI9 (/IDA) Q96SI9 (/IDA) Q96SI9 (/IDA) Q96SI9 (/IDA)
(6 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
7 A0A024R7C7 (/IDA) A0A024R7C7 (/IDA) K7EKJ9 (/IDA) K7EKJ9 (/IDA) K7EKJ9 (/IDA) Q12906 (/IDA) Q12906 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
7 A0A024R7C7 (/IDA) A0A024R7C7 (/IDA) K7EKJ9 (/IDA) K7EKJ9 (/IDA) K7EKJ9 (/IDA) Q12906 (/IDA) Q12906 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
7 A0A024R7C7 (/IDA) A0A024R7C7 (/IDA) K7EKJ9 (/IDA) K7EKJ9 (/IDA) K7EKJ9 (/IDA) Q12906 (/IDA) Q12906 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 Q12906 (/IDA) Q12906 (/IDA) Q2TAV5 (/IDA) Q91550 (/IDA) Q9Z1X4 (/IDA)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
4 Q6DD04 (/ISS) Q6GL57 (/ISS) Q9JIL3 (/ISS) Q9Z1X4 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q6DD04 (/ISS) Q6GL57 (/ISS) Q9JIL3 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q6DD04 (/ISS) Q6GL57 (/ISS) Q9JIL3 (/ISS)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
3 Q12906 (/IDA) Q12906 (/IDA) Q91550 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 Q12906 (/HDA) Q12906 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q91WM1 (/ISO) Q9Z1X4 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q12906 (/NAS) Q12906 (/NAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q12906 (/HDA) Q12906 (/HDA)
Manchette GO:0002177
A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.
1 Q91WM1 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9Z1X4 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9Z1X4 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9Z1X4 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9Z1X4 (/ISO)
Polysome GO:0005844
A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.
1 Q6DD04 (/IDA)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
1 Q91WM1 (/IDA)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
1 Q9Z1X4 (/ISO)
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