The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 18: Phosphodiesterase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
CGMP-stimulated cyclic-nucleotide phosphodiesterase activity GO:0004118
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP.
|
6 | E1BPD8 (/ISS) E2R989 (/ISS) F6WM73 (/ISS) F7B340 (/ISS) P0C1Q2 (/ISS) Q8VID6 (/ISS) |
|
CGMP binding GO:0030553
Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
|
5 | E1BPD8 (/ISS) E2R989 (/ISS) F6WM73 (/ISS) F7B340 (/ISS) P0C1Q2 (/ISS) |
|
Cyclic-nucleotide phosphodiesterase activity GO:0004112
Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.
|
1 | Q8VID6 (/IDA) |
|
Cyclic-nucleotide phosphodiesterase activity GO:0004112
Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.
|
1 | P0C1Q2 (/ISO) |
|
Cyclic-nucleotide phosphodiesterase activity GO:0004112
Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.
|
1 | Q9HCR9 (/NAS) |
|
3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
|
1 | Q9HCR9 (/TAS) |
|
CGMP-stimulated cyclic-nucleotide phosphodiesterase activity GO:0004118
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP.
|
1 | Q9HCR9 (/IDA) |
|
CGMP-stimulated cyclic-nucleotide phosphodiesterase activity GO:0004118
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP.
|
1 | P0C1Q2 (/ISO) |
|
CGMP binding GO:0030553
Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
|
1 | Q9HCR9 (/IDA) |
|
CGMP binding GO:0030553
Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
|
1 | P0C1Q2 (/ISO) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
1 | Q9HCR9 (/TAS) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
1 | Q9HCR9 (/TAS) |
|
Negative regulation of cGMP-mediated signaling GO:0010754
Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
|
1 | Q8VID6 (/IDA) |
|
Negative regulation of cGMP-mediated signaling GO:0010754
Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
|
1 | P0C1Q2 (/ISO) |
|
Negative regulation of cAMP-mediated signaling GO:0043951
Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
|
1 | Q8VID6 (/IDA) |
|
Negative regulation of cAMP-mediated signaling GO:0043951
Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
|
1 | P0C1Q2 (/ISO) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9HCR9 (/TAS) |
|
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
|
1 | Q8VID6 (/IDA) |
|
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
|
1 | P0C1Q2 (/ISO) |
