The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Dynein light chain 2a, cytoplasmic
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Dynein light chain roadblock

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
31 P62627 (/IPI) P62627 (/IPI) P62627 (/IPI) P62627 (/IPI) P62627 (/IPI) P62627 (/IPI) P62627 (/IPI) P62627 (/IPI) P62627 (/IPI) P62627 (/IPI)
(21 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
23 P62627 (/IPI) P62627 (/IPI) P62627 (/IPI) P62627 (/IPI) P62627 (/IPI) P62627 (/IPI) P62627 (/IPI) P62627 (/IPI) P62627 (/IPI) P62627 (/IPI)
(13 more)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
18 Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS)
(8 more)
Dynein intermediate chain binding GO:0045505
Interacting selectively and non-covalently with an intermediate chain of the dynein complex.
17 Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA)
(7 more)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Visual behavior GO:0007632
The behavior of an organism in response to a visual stimulus.
28 P62627 (/ISS) P62627 (/ISS) P62627 (/ISS) P62627 (/ISS) P62627 (/ISS) P62627 (/ISS) P62627 (/ISS) P62627 (/ISS) P62627 (/ISS) P62627 (/ISS)
(18 more)
Visual behavior GO:0007632
The behavior of an organism in response to a visual stimulus.
23 P62628 (/IDA) P62628 (/IDA) P62628 (/IDA) P62628 (/IDA) P62628 (/IDA) P62628 (/IDA) P62628 (/IDA) P62628 (/IDA) P62628 (/IDA) P62628 (/IDA)
(13 more)
Visual behavior GO:0007632
The behavior of an organism in response to a visual stimulus.
23 P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO)
(13 more)
Retrograde axonal transport GO:0008090
The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.
23 P62628 (/NAS) P62628 (/NAS) P62628 (/NAS) P62628 (/NAS) P62628 (/NAS) P62628 (/NAS) P62628 (/NAS) P62628 (/NAS) P62628 (/NAS) P62628 (/NAS)
(13 more)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
23 P62628 (/IEP) P62628 (/IEP) P62628 (/IEP) P62628 (/IEP) P62628 (/IEP) P62628 (/IEP) P62628 (/IEP) P62628 (/IEP) P62628 (/IEP) P62628 (/IEP)
(13 more)
Microtubule-based movement GO:0007018
A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
18 Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS)
(8 more)
Intraciliary transport involved in cilium assembly GO:0035735
The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.
18 Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS)
(8 more)
Microtubule-based movement GO:0007018
A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
16 Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA) Q7KMS3 (/IDA)
(6 more)
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
16 Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP)
(6 more)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
16 Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP)
(6 more)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
16 Q7KMS3 (/TAS) Q7KMS3 (/TAS) Q7KMS3 (/TAS) Q7KMS3 (/TAS) Q7KMS3 (/TAS) Q7KMS3 (/TAS) Q7KMS3 (/TAS) Q7KMS3 (/TAS) Q7KMS3 (/TAS) Q7KMS3 (/TAS)
(6 more)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q7ZUX8 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
69 P62628 (/ISS) P62628 (/ISS) P62628 (/ISS) P62628 (/ISS) P62628 (/ISS) P62628 (/ISS) P62628 (/ISS) P62628 (/ISS) P62628 (/ISS) P62628 (/ISS)
(59 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
28 P62627 (/ISS) P62627 (/ISS) P62627 (/ISS) P62627 (/ISS) P62627 (/ISS) P62627 (/ISS) P62627 (/ISS) P62627 (/ISS) P62627 (/ISS) P62627 (/ISS)
(18 more)
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
26 P62627 (/IDA) P62627 (/IDA) P62627 (/IDA) P62627 (/IDA) P62627 (/IDA) P62627 (/IDA) P62627 (/IDA) P62627 (/IDA) P62627 (/IDA) P62627 (/IDA)
(16 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
23 P62628 (/IDA) P62628 (/IDA) P62628 (/IDA) P62628 (/IDA) P62628 (/IDA) P62628 (/IDA) P62628 (/IDA) P62628 (/IDA) P62628 (/IDA) P62628 (/IDA)
(13 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
23 P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO)
(13 more)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
23 P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO) P62627 (/ISO)
(13 more)
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
18 Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS) Q8TF09 (/NAS)
(8 more)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
18 Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS)
(8 more)
Ciliary tip GO:0097542
Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction.
18 Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS) Q8TF09 (/TAS)
(8 more)
Axonemal dynein complex GO:0005858
A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
16 Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP)
(6 more)
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
16 Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP) Q7KMS3 (/IMP)
(6 more)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
5 Q9NP97 (/IDA) Q9NP97 (/IDA) Q9NP97 (/IDA) Q9NP97 (/IDA) Q9NP97 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 Q9NP97 (/HDA) Q9NP97 (/HDA) Q9NP97 (/HDA) Q9NP97 (/HDA) Q9NP97 (/HDA)
Dynein complex GO:0030286
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
1 Q7ZUX8 (/IDA)
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