The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"PAS domain
".
FunFam 13: Period circadian protein homolog 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 25 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
10 | J3QSH9 (/IPI) O15055 (/IPI) O15534 (/IPI) O35973 (/IPI) O54943 (/IPI) O70361 (/IPI) P56645 (/IPI) P56645 (/IPI) Q8CHI5 (/IPI) Q9Z301 (/IPI) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
4 | O15534 (/IPI) O35973 (/IPI) O54943 (/IPI) O70361 (/IPI) |
|
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
3 | B3DJN7 (/IDA) F1QUT1 (/IDA) Q7T1C9 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
|
3 | O15534 (/ISS) Q8CHI5 (/ISS) Q8K3T3 (/ISS) |
|
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
2 | O35973 (/IDA) O54943 (/IDA) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
2 | O35973 (/IPI) O54943 (/IPI) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
2 | O15534 (/IPI) O70361 (/IPI) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | O15534 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | O35973 (/ISO) |
|
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
|
1 | O54943 (/IDA) |
|
Transcription corepressor binding GO:0001222
Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
|
1 | O54943 (/IPI) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | O54943 (/IDA) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | O35973 (/ISO) |
|
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
|
1 | O35973 (/IDA) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | O35973 (/ISO) |
|
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
|
1 | O54943 (/IPI) |
|
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
|
1 | O54943 (/IDA) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | O54943 (/IPI) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
1 | O54943 (/IPI) |
|
RNA polymerase binding GO:0070063
Interacting selectively and non-covalently with an RNA polymerase molecule or complex.
|
1 | O54943 (/IPI) |
|
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
|
1 | O15534 (/IDA) |
|
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
|
1 | O35973 (/ISO) |
|
Histone methyltransferase binding GO:1990226
Interacting selectively and non-covalently with a histone methyltransferase enzyme.
|
1 | O54943 (/IPI) |
There are 106 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Photoperiodism GO:0009648
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species.
|
10 | A0A0R4ICG0 (/IEP) A0A2R8Q8Q0 (/IEP) B3DGP6 (/IEP) B3DJN2 (/IEP) B3DJN7 (/IEP) F1QUT1 (/IEP) F1RDZ4 (/IEP) Q7SZZ4 (/IEP) Q7T1C9 (/IEP) Q9I8L4 (/IEP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
7 | O35973 (/IDA) O54943 (/IDA) O70361 (/IDA) P56645 (/IDA) P56645 (/IDA) Q5BJ30 (/IDA) Q9Z301 (/IDA) |
|
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
|
7 | B3DJN7 (/IEP) B3DK47 (/IEP) F1QUT1 (/IEP) O35973 (/IEP) Q6E2N4 (/IEP) Q6UV33 (/IEP) Q7T1C9 (/IEP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
6 | O15055 (/ISS) O15534 (/ISS) Q8CHI5 (/ISS) Q8CJE2 (/ISS) Q8K3T2 (/ISS) Q8K3T3 (/ISS) |
|
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
|
6 | B3DJN7 (/IDA) B3DK47 (/IDA) F1QUT1 (/IDA) Q6E2N4 (/IDA) Q6UV33 (/IDA) Q7T1C9 (/IDA) |
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
6 | A0A2R8Q8Q0 (/IMP) B3DGP6 (/IMP) F1RDZ4 (/IMP) O35973 (/IMP) O54943 (/IMP) Q9I8L4 (/IMP) |
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
6 | O15055 (/ISS) O35973 (/ISS) Q8CHI5 (/ISS) Q8K3T2 (/ISS) Q8K3T3 (/ISS) Q9Z301 (/ISS) |
|
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
6 | A0A0R4ICG0 (/IEP) B3DJN2 (/IEP) B3DJN7 (/IEP) F1QUT1 (/IEP) Q7SZZ4 (/IEP) Q7T1C9 (/IEP) |
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
6 | O15055 (/ISS) O15534 (/ISS) Q8CHI5 (/ISS) Q8K3T2 (/ISS) Q8K3T3 (/ISS) Q9Z301 (/ISS) |
|
Histone H3 deacetylation GO:0070932
The modification of histone H3 by the removal of one or more acetyl groups.
|
6 | O15055 (/ISS) O15534 (/ISS) Q8CHI5 (/ISS) Q8K3T2 (/ISS) Q8K3T3 (/ISS) Q9Z301 (/ISS) |
|
Circadian regulation of translation GO:0097167
Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours.
|
6 | O15055 (/ISS) O15534 (/ISS) Q8CHI5 (/ISS) Q8K3T2 (/ISS) Q8K3T3 (/ISS) Q9Z301 (/ISS) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
5 | O15534 (/IEP) O35973 (/IEP) O54943 (/IEP) Q8CHI5 (/IEP) Q9Z301 (/IEP) |
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
5 | B3DK47 (/IMP) O35973 (/IMP) O54943 (/IMP) Q6E2N4 (/IMP) Q6UV33 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | O15055 (/ISS) O15534 (/ISS) Q8CHI5 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
|
4 | B3DJN7 (/IMP) F1QUT1 (/IMP) O35973 (/IMP) Q7T1C9 (/IMP) |
|
Regulation of sodium ion transport GO:0002028
Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
3 | O15534 (/ISS) Q8CHI5 (/ISS) Q8K3T3 (/ISS) |
|
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Glycogen biosynthetic process GO:0005978
The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
|
3 | B3DK47 (/IMP) Q6E2N4 (/IMP) Q6UV33 (/IMP) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
3 | O54943 (/IDA) O70361 (/IDA) Q8QGQ8 (/IDA) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
3 | O15055 (/TAS) O15534 (/TAS) O35973 (/TAS) |
|
Response to temperature stimulus GO:0009266
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
|
3 | B3DK47 (/IDA) Q6E2N4 (/IDA) Q6UV33 (/IDA) |
|
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
|
3 | B3DJN7 (/IDA) F1QUT1 (/IDA) Q7T1C9 (/IDA) |
|
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
|
3 | B3DJN7 (/IDA) F1QUT1 (/IDA) Q7T1C9 (/IDA) |
|
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
|
3 | O15534 (/ISS) Q8CHI5 (/ISS) Q8K3T3 (/ISS) |
|
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
3 | B3DJN7 (/IMP) F1QUT1 (/IMP) Q7T1C9 (/IMP) |
|
Regulation of vasoconstriction GO:0019229
Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Lactate biosynthetic process GO:0019249
The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
3 | O15534 (/IDA) O35973 (/IDA) O54943 (/IDA) |
|
Regulation of hair cycle GO:0042634
Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.
|
3 | O35973 (/ISS) Q8CHI5 (/ISS) Q8K3T3 (/ISS) |
|
Positive regulation of circadian rhythm GO:0042753
Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.
|
3 | B3DJN7 (/IMP) F1QUT1 (/IMP) Q7T1C9 (/IMP) |
|
Negative regulation of circadian rhythm GO:0042754
Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
|
3 | O15534 (/ISS) O35973 (/ISS) Q8K3T3 (/ISS) |
|
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
|
3 | O15534 (/ISS) Q8CHI5 (/ISS) Q8K3T3 (/ISS) |
|
Regulation of circadian sleep/wake cycle, sleep GO:0045187
Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
|
3 | O70361 (/IMP) P56645 (/IMP) P56645 (/IMP) |
|
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
|
3 | B3DJN7 (/IMP) F1QUT1 (/IMP) Q7T1C9 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | O35973 (/IDA) O54943 (/IDA) Q9Z301 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | O15534 (/ISS) Q8CHI5 (/ISS) Q8K3T3 (/ISS) |
|
Negative regulation of JNK cascade GO:0046329
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
3 | O15534 (/ISS) O35973 (/ISS) Q8K3T3 (/ISS) |
|
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
White fat cell differentiation GO:0050872
The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Regulation of glutamate uptake involved in transmission of nerve impulse GO:0051946
Any process that modulates the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
|
3 | B3DK47 (/IMP) Q6E2N4 (/IMP) Q6UV33 (/IMP) |
|
Negative regulation of fat cell proliferation GO:0070345
Any process that stops or decreases the rate or extent of fat cell proliferation.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Dopaminergic neuron differentiation GO:0071542
The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
|
3 | B3DK47 (/IMP) Q6E2N4 (/IMP) Q6UV33 (/IMP) |
|
Regulation of cytokine production involved in inflammatory response GO:1900015
Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.
|
3 | O15534 (/ISS) O35973 (/ISS) Q8K3T3 (/ISS) |
|
Regulation of p38MAPK cascade GO:1900744
Any process that modulates the frequency, rate or extent of p38MAPK cascade.
|
3 | O15534 (/ISS) O35973 (/ISS) Q8K3T3 (/ISS) |
|
Positive regulation of dopaminergic neuron differentiation GO:1904340
Any process that activates or increases the frequency, rate or extent of dopaminergic neuron differentiation.
|
3 | B3DK47 (/IMP) Q6E2N4 (/IMP) Q6UV33 (/IMP) |
|
Negative regulation of glucocorticoid receptor signaling pathway GO:2000323
Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway.
|
3 | O15534 (/ISS) Q8CHI5 (/ISS) Q8K3T3 (/ISS) |
|
Negative regulation of transcription regulatory region DNA binding GO:2000678
Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding.
|
3 | O15055 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | O35973 (/IMP) O54943 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | O54943 (/ISO) O70361 (/ISO) |
|
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
|
2 | O15534 (/IDA) O35973 (/IDA) |
|
Regulation of circadian sleep/wake cycle, sleep GO:0045187
Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
|
2 | O70361 (/ISS) Q8CJE2 (/ISS) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
2 | P56645 (/IMP) P56645 (/IMP) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
2 | O70361 (/ISS) Q8CJE2 (/ISS) |
|
Histone H3 deacetylation GO:0070932
The modification of histone H3 by the removal of one or more acetyl groups.
|
2 | O35973 (/IMP) O54943 (/IMP) |
|
Circadian regulation of translation GO:0097167
Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours.
|
2 | O35973 (/IMP) O54943 (/IMP) |
|
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
|
2 | O15055 (/ISS) Q9Z301 (/ISS) |
|
Regulation of sodium ion transport GO:0002028
Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | O35973 (/IMP) |
|
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
|
1 | O54943 (/IMP) |
|
Glycogen biosynthetic process GO:0005978
The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
|
1 | O54943 (/IMP) |
|
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
|
1 | O54943 (/IMP) |
|
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
|
1 | O54943 (/IMP) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
1 | Q8CHI5 (/IMP) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
1 | O35973 (/ISO) |
|
Entrainment of circadian clock GO:0009649
The synchronization of a circadian rhythm to environmental time cues such as light.
|
1 | O15534 (/TAS) |
|
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
|
1 | O35973 (/IMP) |
|
Regulation of vasoconstriction GO:0019229
Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels.
|
1 | O54943 (/IMP) |
|
Lactate biosynthetic process GO:0019249
The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid.
|
1 | O54943 (/IMP) |
|
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
1 | O54943 (/IDA) |
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
1 | O35973 (/ISO) |
|
Regulation of hair cycle GO:0042634
Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.
|
1 | O15534 (/IMP) |
|
Regulation of hair cycle GO:0042634
Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.
|
1 | O35973 (/ISO) |
|
Negative regulation of circadian rhythm GO:0042754
Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
|
1 | O54943 (/IDA) |
|
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
|
1 | Q8CHI5 (/IMP) |
|
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
|
1 | O35973 (/ISO) |
|
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
|
1 | O35973 (/ISO) |
|
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
|
1 | O15534 (/IDA) |
|
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
|
1 | O35973 (/ISO) |
|
Regulation of circadian sleep/wake cycle, sleep GO:0045187
Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
|
1 | O70361 (/ISO) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | O54943 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | O35973 (/IMP) |
|
Negative regulation of JNK cascade GO:0046329
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
1 | Q8CHI5 (/IMP) |
|
Negative regulation of JNK cascade GO:0046329
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
1 | O35973 (/ISO) |
|
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
|
1 | O54943 (/IMP) |
|
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
|
1 | O54943 (/IMP) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
1 | O70361 (/ISO) |
|
White fat cell differentiation GO:0050872
The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole.
|
1 | O54943 (/IMP) |
|
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
|
1 | O35973 (/IDA) |
|
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
|
1 | O54943 (/IMP) |
|
Regulation of glutamate uptake involved in transmission of nerve impulse GO:0051946
Any process that modulates the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell.
|
1 | O54943 (/IMP) |
|
Negative regulation of DNA-templated transcription, termination GO:0060567
Any process that decreases the rate, frequency or extent of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA.
|
1 | O54943 (/IDA) |
|
Negative regulation of fat cell proliferation GO:0070345
Any process that stops or decreases the rate or extent of fat cell proliferation.
|
1 | O54943 (/IMP) |
|
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
|
1 | O54943 (/IMP) |
|
Regulation of cytokine production involved in inflammatory response GO:1900015
Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.
|
1 | Q8CHI5 (/IMP) |
|
Regulation of cytokine production involved in inflammatory response GO:1900015
Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.
|
1 | O35973 (/ISO) |
|
Regulation of p38MAPK cascade GO:1900744
Any process that modulates the frequency, rate or extent of p38MAPK cascade.
|
1 | Q8CHI5 (/IMP) |
|
Regulation of p38MAPK cascade GO:1900744
Any process that modulates the frequency, rate or extent of p38MAPK cascade.
|
1 | O35973 (/ISO) |
|
Negative regulation of glucocorticoid receptor signaling pathway GO:2000323
Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway.
|
1 | O35973 (/IMP) |
|
Negative regulation of transcription regulatory region DNA binding GO:2000678
Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding.
|
1 | O54943 (/IMP) |
There are 14 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | O15055 (/IDA) O35973 (/IDA) O54943 (/IDA) P56645 (/IDA) P56645 (/IDA) Q8CHI5 (/IDA) Q9Z301 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | O15055 (/ISS) O70361 (/ISS) Q8CJE2 (/ISS) Q8K3T2 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | O15534 (/IDA) O54943 (/IDA) P56645 (/IDA) P56645 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | O70361 (/ISS) Q8CJE2 (/ISS) Q8K3T2 (/ISS) Q9Z301 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O35973 (/ISO) O54943 (/ISO) O70361 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | O35973 (/TAS) O54943 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | O35973 (/ISO) O70361 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | O35973 (/TAS) O54943 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O54943 (/IPI) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | O15534 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | O35973 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O15534 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O35973 (/ISO) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | O54943 (/IDA) |
