The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"HIT-like
".
FunFam 17: Aprataxin-like protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA 5'-adenosine monophosphate hydrolase activity GO:0033699
Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus.
|
5 | O74859 (/IDA) Q08702 (/IDA) Q08702 (/IDA) Q08702 (/IDA) Q08702 (/IDA) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
1 | O74859 (/IDA) |
|
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
1 | O74859 (/IDA) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | O74859 (/IDA) |
|
GMP binding GO:0019002
Interacting selectively and non-covalently with GMP, guanosine monophosphate.
|
1 | O74859 (/IDA) |
|
Mismatched DNA binding GO:0030983
Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches.
|
1 | O74859 (/IDA) |
|
DNA-3'-diphospho-5'-guanosine diphosphatase GO:0120108
Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H(2)O <=> (DNA)-3'-phosphate + GMP.
|
1 | O74859 (/IDA) |
|
Guanosine binding GO:1905108
Interacting selectively and non-covalently with guanosine.
|
1 | O74859 (/IDA) |
|
Single-strand break-containing DNA binding GO:1990165
Interacting selectively and non-covalently with damaged DNA containing single-strand breaks (SSBs).
|
1 | O74859 (/IDA) |
There are 3 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
4 | Q08702 (/IGI) Q08702 (/IGI) Q08702 (/IGI) Q08702 (/IGI) |
|
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
4 | Q08702 (/IMP) Q08702 (/IMP) Q08702 (/IMP) Q08702 (/IMP) |
|
Mismatch repair GO:0006298
A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
|
1 | O74859 (/IDA) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | O74859 (/HDA) Q08702 (/HDA) Q08702 (/HDA) Q08702 (/HDA) Q08702 (/HDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | Q08702 (/HDA) Q08702 (/HDA) Q08702 (/HDA) Q08702 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O74859 (/HDA) |
