The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
HIT-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Galactose-1-phosphate uridylyltransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
UDP-glucose:hexose-1-phosphate uridylyltransferase activity GO:0008108
Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose.
34 P07902 (/IDA) P07902 (/IDA) P08431 (/IDA) P08431 (/IDA) P08431 (/IDA) P08431 (/IDA) P08431 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA)
(24 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
27 P07902 (/IDA) P07902 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA)
(17 more)
Galactokinase activity GO:0004335
Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+).
25 P09148 (/IMP) P09148 (/IMP) P09148 (/IMP) P09148 (/IMP) P09148 (/IMP) P09148 (/IMP) P09148 (/IMP) P09148 (/IMP) P09148 (/IMP) P09148 (/IMP)
(15 more)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
25 P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA)
(15 more)
UDP-glucose:hexose-1-phosphate uridylyltransferase activity GO:0008108
Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose.
9 E9QE09 (/IMP) P08431 (/IMP) P08431 (/IMP) P08431 (/IMP) P08431 (/IMP) P08431 (/IMP) Q9HDU5 (/IMP) Q9VMA2 (/IMP) Q9VMA2 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P07902 (/IPI) P07902 (/IPI)
UDP-glucose:hexose-1-phosphate uridylyltransferase activity GO:0008108
Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose.
2 P07902 (/EXP) P07902 (/EXP)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 P43424 (/ISS) Q03249 (/ISS)
Galactose binding GO:0005534
Interacting selectively and non-covalently with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides.
1 P43424 (/IC)
Glucose binding GO:0005536
Interacting selectively and non-covalently with the D- or L-enantiomer of glucose.
1 P43424 (/IC)
UDP-glucose:hexose-1-phosphate uridylyltransferase activity GO:0008108
Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose.
1 Q03249 (/ISO)
UDP-glucose:hexose-1-phosphate uridylyltransferase activity GO:0008108
Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose.
1 C8V226 (/RCA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q03249 (/ISO)
UTP:galactose-1-phosphate uridylyltransferase activity GO:0017103
Catalysis of the reaction: alpha-D-galactose 1-phosphate + UTP = diphosphate + UDP-D-galactose.
1 C8V226 (/RCA)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Galactose catabolic process via UDP-galactose GO:0033499
The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose.
31 E9QE09 (/IMP) P08431 (/IMP) P08431 (/IMP) P08431 (/IMP) P08431 (/IMP) P08431 (/IMP) P09148 (/IMP) P09148 (/IMP) P09148 (/IMP) P09148 (/IMP)
(21 more)
Galactose catabolic process via UDP-galactose GO:0033499
The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose.
5 P08431 (/IDA) P08431 (/IDA) P08431 (/IDA) P08431 (/IDA) P08431 (/IDA)
Galactose metabolic process GO:0006012
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
3 P07902 (/IDA) P07902 (/IDA) P43424 (/IDA)
UDP-glucose metabolic process GO:0006011
The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate.
2 P07902 (/IDA) P07902 (/IDA)
Galactose metabolic process GO:0006012
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
2 Q03249 (/IMP) Q9HDU5 (/IMP)
Galactose metabolic process GO:0006012
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
2 P07902 (/TAS) P07902 (/TAS)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
2 Q9VMA2 (/IMP) Q9VMA2 (/IMP)
Galactose catabolic process GO:0019388
The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose.
2 P07902 (/TAS) P07902 (/TAS)
Galactose homeostasis GO:0033501
A homeostatic process involved in the maintenance of an internal steady state of galactose within an organism or cell.
2 Q9VMA2 (/IMP) Q9VMA2 (/IMP)
UDP-glucose metabolic process GO:0006011
The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate.
1 Q03249 (/ISO)
UDP-glucose metabolic process GO:0006011
The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate.
1 Q03249 (/ISS)
Galactose metabolic process GO:0006012
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
1 Q03249 (/ISO)
Galactose metabolic process GO:0006012
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
1 Q03249 (/ISS)
Galactose metabolic process GO:0006012
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
1 C8V226 (/RCA)
UDP-glucose catabolic process GO:0006258
The chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate.
1 P43424 (/IDA)
UDP-glucose catabolic process GO:0006258
The chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate.
1 Q03249 (/ISO)
Galactose catabolic process GO:0019388
The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose.
1 A0A1D8PCM2 (/IMP)
Galactose catabolic process via UDP-galactose GO:0033499
The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose.
1 Q03249 (/IC)
Galactose catabolic process via UDP-galactose GO:0033499
The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose.
1 Q9HDU5 (/ISO)
Protein galactosylation GO:0042125
The addition of a galactose molecule to a protein amino acid.
1 Q9HDU5 (/IMP)
UDP-D-galactose biosynthetic process GO:0052574
The chemical reactions and pathways resulting in the formation of UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate.
1 Q9HDU5 (/IMP)
Glycolytic process from galactose GO:0061623
The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP.
1 Q03249 (/IC)
Glycolytic process from galactose GO:0061623
The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP.
1 Q03249 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
25 P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA) P09148 (/IDA)
(15 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P08431 (/IDA) P08431 (/IDA) P08431 (/IDA) P08431 (/IDA) P08431 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 P07902 (/IDA) P07902 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P07902 (/TAS) P07902 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9HDU5 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q03249 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9HDU5 (/HDA)
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