The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SEP domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1: NSFL1 (P97) cofactor (P47)

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
12 O35987 (/IPI) Q14CS0 (/IPI) Q14CS0 (/IPI) Q14CS0 (/IPI) Q14CS0 (/IPI) Q9CZ44 (/IPI) Q9UNZ2 (/IPI) Q9UNZ2 (/IPI) Q9UNZ2 (/IPI) Q9UNZ2 (/IPI)
(2 more)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
1 O35987 (/IDA)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
1 Q9CZ44 (/ISO)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
1 O35987 (/IPI)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
1 Q9CZ44 (/ISO)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
10 Q14CS0 (/IGI) Q14CS0 (/IGI) Q14CS0 (/IGI) Q14CS0 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI)
Positive regulation of mitotic centrosome separation GO:0046604
Any process that activates or increases the frequency, rate or extent of centrosome separation.
10 Q14CS0 (/IGI) Q14CS0 (/IGI) Q14CS0 (/IGI) Q14CS0 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI)
Negative regulation of protein localization to centrosome GO:1904780
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome.
10 Q14CS0 (/IGI) Q14CS0 (/IGI) Q14CS0 (/IGI) Q14CS0 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI) Q9UNZ2 (/IGI)
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
2 Q0KL01 (/ISO) Q9CZ44 (/ISO)
Positive regulation of mitotic centrosome separation GO:0046604
Any process that activates or increases the frequency, rate or extent of centrosome separation.
2 Q0KL01 (/ISO) Q9CZ44 (/ISO)
Negative regulation of protein localization to centrosome GO:1904780
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome.
2 Q0KL01 (/ISO) Q9CZ44 (/ISO)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
1 O35987 (/IDA)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
1 Q9CZ44 (/ISO)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
1 Q5ZK10 (/ISS)
Nuclear envelope reassembly GO:0031468
The reformation of the nuclear envelope following its breakdown in the context of a normal process.
1 Q7K3Z3 (/IMP)
Rhabdomere development GO:0042052
The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments.
1 Q7K3Z3 (/IMP)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
1 O35987 (/IDA)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
1 Q9CZ44 (/ISO)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
1 Q5ZK10 (/ISS)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 O35987 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
6 Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA) Q9UNZ2 (/IDA)
VCP-NSFL1C complex GO:1990730
A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.
6 Q9UNZ2 (/ISS) Q9UNZ2 (/ISS) Q9UNZ2 (/ISS) Q9UNZ2 (/ISS) Q9UNZ2 (/ISS) Q9UNZ2 (/ISS)
Spindle pole centrosome GO:0031616
A centrosome from which one pole of a mitotic or meiotic spindle is organized.
2 O35987 (/IDA) Q0KL01 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q7K3Z3 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9CZ44 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q7K3Z3 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9CZ44 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9CZ44 (/ISO)
Spindle pole centrosome GO:0031616
A centrosome from which one pole of a mitotic or meiotic spindle is organized.
1 Q9CZ44 (/ISO)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
1 Q9CZ44 (/ISO)
VCP-NSFL1C complex GO:1990730
A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.
1 O35987 (/IPI)
VCP-NSFL1C complex GO:1990730
A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.
1 Q9CZ44 (/ISO)