The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribonuclease H-like superfamily/Ribonuclease H
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: protein argonaute 10-like

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 D6RUV9 (/IPI) O04379 (/IPI) O04379 (/IPI) Q9XGW1 (/IPI) Q9XGW1 (/IPI)
MiRNA binding GO:0035198
Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.
4 O04379 (/IDA) O04379 (/IDA) Q9XGW1 (/IDA) Q9XGW1 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
2 O04379 (/IDA) O04379 (/IDA)
Endoribonuclease activity GO:0004521
Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
2 O04379 (/IDA) O04379 (/IDA)
MiRNA binding GO:0035198
Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.
2 O04379 (/IPI) O04379 (/IPI)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
1 Q69VD5 (/ISS)
SiRNA binding GO:0035197
Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
1 Q851R2 (/ISS)

There are 37 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
5 O04379 (/IDA) O04379 (/IDA) Q9C793 (/IDA) Q9XGW1 (/IDA) Q9XGW1 (/IDA)
Viral gene silencing in virus induced gene silencing GO:0060145
The posttranscriptional gene silencing of viral genes after viral infection.
3 O04379 (/IMP) O04379 (/IMP) Q9C793 (/IMP)
Virus induced gene silencing GO:0009616
Specific posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes. This silencing is triggered by viral infection, and occurs through a specific decrease in the level of mRNA of both host and viral genes.
2 O04379 (/IDA) O04379 (/IDA)
Response to auxin GO:0009733
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus.
2 O04379 (/IGI) O04379 (/IGI)
Auxin metabolic process GO:0009850
The chemical reactions and pathways involving auxins, a group of plant hormones that regulate aspects of plant growth.
2 O04379 (/IGI) O04379 (/IGI)
Regulation of meristem structural organization GO:0009934
Any process that modulates the frequency, rate or extent of meristem organization.
2 Q9XGW1 (/IMP) Q9XGW1 (/IMP)
Adaxial/abaxial pattern specification GO:0009955
The regionalization process in which differences in cell differentiation along the adaxial/abaxial are generated. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure.
2 O04379 (/IMP) O04379 (/IMP)
Leaf morphogenesis GO:0009965
The process in which the anatomical structures of the leaf are generated and organized.
2 O04379 (/IMP) O04379 (/IMP)
Response to far red light GO:0010218
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
2 O04379 (/IGI) O04379 (/IGI)
Leaf vascular tissue pattern formation GO:0010305
Vascular tissue pattern formation as it occurs in the leaf of vascular plants.
2 O04379 (/IMP) O04379 (/IMP)
MiRNA metabolic process GO:0010586
The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
2 Q9XGW1 (/IMP) Q9XGW1 (/IMP)
Leaf proximal/distal pattern formation GO:0010589
The regionalization process within a leaf by which specific areas of cell differentiation are determined along a proximal/distal axis.
2 O04379 (/IMP) O04379 (/IMP)
Posttranscriptional gene silencing GO:0016441
The inactivation of gene expression by a posttranscriptional mechanism.
2 O04379 (/IEP) O04379 (/IEP)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
2 O04379 (/IGI) O04379 (/IGI)
Somatic stem cell population maintenance GO:0035019
Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
2 Q9XGW1 (/IMP) Q9XGW1 (/IMP)
Gene silencing by miRNA GO:0035195
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
2 O04379 (/IEP) O04379 (/IEP)
Gene silencing by miRNA GO:0035195
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
2 O04379 (/IMP) O04379 (/IMP)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
2 O04379 (/IMP) O04379 (/IMP)
Adventitious root development GO:0048830
The process whose specific outcome is the progression of adventitious root over time, from its formation to the mature structure. Adventitious roots are post-embryonic roots that develop from the plant shoot.
2 O04379 (/IMP) O04379 (/IMP)
Regulation of shoot apical meristem development GO:1902183
Any process that modulates the frequency, rate or extent of shoot apical meristem development.
2 Q9XGW1 (/IMP) Q9XGW1 (/IMP)
Male meiotic nuclear division GO:0007140
A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
1 Q851R2 (/IMP)
Female meiotic nuclear division GO:0007143
A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.
1 Q851R2 (/IMP)
Megagametogenesis GO:0009561
The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center.
1 Q851R2 (/IMP)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 Q9SJK3 (/IEP)
Defense response, incompatible interaction GO:0009814
A response of a plant to a pathogenic agent that prevents the occurrence or spread of disease.
1 Q9SJK3 (/IEP)
Vegetative phase change GO:0010050
Any process involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development.
1 Q9C793 (/IMP)
Production of ta-siRNAs involved in RNA interference GO:0010267
Cleavage of double-stranded RNA to form trans-acting small interfering RNA molecules (siRNAs) of 21-23 nucleotides. ta-siRNAs arise from PolII genes and function like miRNAs to guide cleavage of target mRNAs.
1 Q9C793 (/IMP)
Maintenance of shoot apical meristem identity GO:0010492
The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate.
1 Q75HC2 (/IMP)
Production of lsiRNA involved in RNA interference GO:0010599
Cleavage of double-stranded RNA to form lsiRNA (long small interfering RNA), a class of siRNAs 30 to 40 nt in length. lsiRNAs are induced by pathogen infection or under specific growth conditions.
1 Q9C793 (/IMP)
RNA interference GO:0016246
The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
1 Q75HC2 (/IMP)
Stem cell population maintenance GO:0019827
The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
1 Q69VD5 (/IMP)
Histone H3-K9 demethylation GO:0033169
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.
1 Q851R2 (/IDA)
Gene silencing by miRNA GO:0035195
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
1 Q9C793 (/TAS)
Regulation of development, heterochronic GO:0040034
Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.
1 Q9C793 (/IMP)
Leaf development GO:0048366
The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure.
1 Q69VD5 (/IMP)
Microgametogenesis GO:0055046
The process whose specific outcome is the progression of the pollen grain over time, from its formation as the microspore to the mature structure.
1 Q851R2 (/IMP)
Viral gene silencing in virus induced gene silencing GO:0060145
The posttranscriptional gene silencing of viral genes after viral infection.
1 Q9SJK3 (/IGI)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 O04379 (/IDA) O04379 (/IDA) Q69VD5 (/IDA) Q9C793 (/IDA) Q9XGW1 (/IDA) Q9XGW1 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 O04379 (/IDA) O04379 (/IDA) Q9SJK3 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O04379 (/IDA) O04379 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O04379 (/TAS) O04379 (/TAS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q851R2 (/IMP)
Nucleolus organizer region GO:0005731
A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed.
1 Q851R2 (/IMP)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q851R2 (/RCA)