The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Transcription elongation factor SPT4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
58 P63272 (/IPI) P63272 (/IPI) P63272 (/IPI) P63272 (/IPI) P63272 (/IPI) P63272 (/IPI) P63272 (/IPI) P63272 (/IPI) P63272 (/IPI) P63272 (/IPI)
(48 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
56 P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS)
(46 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
56 P63272 (/IPI) P63272 (/IPI) P63272 (/IPI) P63272 (/IPI) P63272 (/IPI) P63272 (/IPI) P63272 (/IPI) P63272 (/IPI) P63272 (/IPI) P63272 (/IPI)
(46 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
56 P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO)
(46 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 Q9TVQ5 (/ISS) Q9TVQ5 (/ISS)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
58 P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA)
(48 more)
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
58 P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA)
(48 more)
Negative regulation of DNA-templated transcription, elongation GO:0032785
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
58 P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA)
(48 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
56 P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO)
(46 more)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
56 P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS)
(46 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
56 P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS)
(46 more)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
56 P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS)
(46 more)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
56 P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS)
(46 more)
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
56 P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO)
(46 more)
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
56 P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS)
(46 more)
Negative regulation of DNA-templated transcription, elongation GO:0032785
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
56 P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO)
(46 more)
Positive regulation of DNA-templated transcription, elongation GO:0032786
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
56 P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA)
(46 more)
Positive regulation of DNA-templated transcription, elongation GO:0032786
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
56 P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO)
(46 more)
Negative regulation of transcription elongation from RNA polymerase II promoter GO:0034244
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
56 P63271 (/IMP) P63271 (/IMP) P63271 (/IMP) P63271 (/IMP) P63271 (/IMP) P63271 (/IMP) P63271 (/IMP) P63271 (/IMP) P63271 (/IMP) P63271 (/IMP)
(46 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
56 P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA)
(46 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
56 P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO)
(46 more)
Positive regulation of viral transcription GO:0050434
Any process that activates or increases the frequency, rate or extent of viral transcription.
56 P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS)
(46 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q9TVQ5 (/ISS) Q9TVQ5 (/ISS)
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
2 Q9TVQ5 (/ISS) Q9TVQ5 (/ISS)
Negative regulation of DNA-templated transcription, elongation GO:0032785
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
2 Q9TVQ5 (/ISS) Q9TVQ5 (/ISS)
Positive regulation of DNA-templated transcription, elongation GO:0032786
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
2 Q9TVQ5 (/ISS) Q9TVQ5 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 Q9TVQ5 (/ISS) Q9TVQ5 (/ISS)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DSIF complex GO:0032044
A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.
174 P63271 (/ISS) P63271 (/ISS) P63271 (/ISS) P63271 (/ISS) P63271 (/ISS) P63271 (/ISS) P63271 (/ISS) P63271 (/ISS) P63271 (/ISS) P63271 (/ISS)
(164 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
58 P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA)
(48 more)
DSIF complex GO:0032044
A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.
58 P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA) P63272 (/IDA)
(48 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
56 P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO)
(46 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
56 P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS)
(46 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
56 P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS) P63272 (/TAS)
(46 more)
DSIF complex GO:0032044
A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.
56 P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO) P63271 (/ISO)
(46 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9TVQ5 (/ISS) Q9TVQ5 (/ISS)
Polytene chromosome puff GO:0005703
A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription.
2 Q9TVQ5 (/IDA) Q9TVQ5 (/IDA)
Polytene chromosome interband GO:0005705
A stretch of less tightly packed chromatin along the polytene chromosome, found between bands.
2 Q9TVQ5 (/IDA) Q9TVQ5 (/IDA)
Transcription elongation factor complex GO:0008023
Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.
2 Q9TVQ5 (/IDA) Q9TVQ5 (/IDA)
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