The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Zinc/RING finger domain, C3HC4 (zinc finger)
".
FunFam 50: E3 ubiquitin-protein ligase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 24 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
36 |
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
(26 more) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
32 |
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
(22 more) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
26 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(16 more) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
17 |
Q06985 (/ISS)
Q7ZVG6 (/ISS)
Q7ZVG6 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
(7 more) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
17 |
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
(7 more) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
14 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(4 more) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
14 |
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
(4 more) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
14 |
P61092 (/IDA)
P61092 (/IDA)
P61092 (/IDA)
P61092 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
(4 more) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
10 | P61092 (/IDA) P61092 (/IDA) P61092 (/IDA) P61092 (/IDA) Q06986 (/IDA) Q06986 (/IDA) Q920M9 (/IDA) Q920M9 (/IDA) Q920M9 (/IDA) Q920M9 (/IDA) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
10 | Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) |
Showing 1 to 10 of 24 entries
There are 46 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
34 |
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
(24 more) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
24 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(14 more) |
|
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
|
24 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(14 more) |
|
Negative regulation of netrin-activated signaling pathway GO:1902842
Any process that stops, prevents or reduces the frequency, rate or extent of netrin-activated signaling pathway.
|
24 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(14 more) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
20 |
P61092 (/IDA)
P61092 (/IDA)
P61092 (/IDA)
P61092 (/IDA)
Q06986 (/IDA)
Q06986 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
(10 more) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
17 |
Q06985 (/ISS)
Q7ZVG6 (/ISS)
Q7ZVG6 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
(7 more) |
|
Neuron apoptotic process GO:0051402
Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
|
17 |
P61092 (/ISS)
P61092 (/ISS)
P61092 (/ISS)
P61092 (/ISS)
Q06985 (/ISS)
Q7ZVG6 (/ISS)
Q7ZVG6 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
(7 more) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
16 |
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
(6 more) |
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
16 |
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
(6 more) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
14 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(4 more) |
Showing 1 to 10 of 46 entries
There are 24 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
24 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(14 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
24 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(14 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
19 |
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
(9 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
17 |
P61092 (/ISS)
P61092 (/ISS)
P61092 (/ISS)
P61092 (/ISS)
Q06985 (/ISS)
Q7ZVG6 (/ISS)
Q7ZVG6 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
(7 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
14 |
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
(4 more) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
14 |
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
(4 more) |
|
Beta-catenin destruction complex GO:0030877
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
|
10 | Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
7 | P61092 (/ISS) P61092 (/ISS) P61092 (/ISS) P61092 (/ISS) Q06985 (/ISS) Q7ZVG6 (/ISS) Q7ZVG6 (/ISS) |
|
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
|
6 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) Q06986 (/ISO) Q06986 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
6 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) Q06986 (/ISO) Q06986 (/ISO) |
Showing 1 to 10 of 24 entries
