The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Zinc/RING finger domain, C3HC4 (zinc finger)
".
FunFam 5: zinc finger protein isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
27 |
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
(17 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
27 |
Q92785 (/NAS)
Q92785 (/NAS)
Q92785 (/NAS)
Q92785 (/NAS)
Q92785 (/NAS)
Q92785 (/NAS)
Q92785 (/NAS)
Q92785 (/NAS)
Q92785 (/NAS)
Q92785 (/NAS)
(17 more) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
27 |
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
(17 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
27 |
Q92785 (/IPI)
Q92785 (/IPI)
Q92785 (/IPI)
Q92785 (/IPI)
Q92785 (/IPI)
Q92785 (/IPI)
Q92785 (/IPI)
Q92785 (/IPI)
Q92785 (/IPI)
Q92785 (/IPI)
(17 more) |
|
H3K9me3 modified histone binding GO:0062072
Interacting selectively and non-covalently with a histone H3 in which the lysine residue at position 9 has been modified by trimethylation.
|
27 |
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
(17 more) |
|
Lysine-acetylated histone binding GO:0070577
Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation.
|
27 |
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
(17 more) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
15 |
Q92784 (/NAS)
Q92784 (/NAS)
Q92784 (/NAS)
Q92784 (/NAS)
Q92784 (/NAS)
Q92784 (/NAS)
Q92784 (/NAS)
Q92784 (/NAS)
Q92784 (/NAS)
Q92784 (/NAS)
(5 more) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
4 | A0A0B4KEC3 (/ISM) A1Z6E6 (/ISM) Q0E9P4 (/ISM) Q7K3G5 (/ISM) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | A9LMC0 (/ISS) |
|
H3K9me3 modified histone binding GO:0062072
Interacting selectively and non-covalently with a histone H3 in which the lysine residue at position 9 has been modified by trimethylation.
|
1 | Q61103 (/ISO) |
|
Lysine-acetylated histone binding GO:0070577
Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation.
|
1 | Q61103 (/ISO) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
38 |
Q92782 (/TAS)
Q92782 (/TAS)
Q92782 (/TAS)
Q92782 (/TAS)
Q92782 (/TAS)
Q92782 (/TAS)
Q92782 (/TAS)
Q92782 (/TAS)
Q92782 (/TAS)
Q92782 (/TAS)
(28 more) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
27 |
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
(17 more) |
|
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
|
27 |
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
Q92785 (/TAS)
(17 more) |
|
Negative regulation of myeloid progenitor cell differentiation GO:1905454
Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation.
|
27 |
Q92785 (/IMP)
Q92785 (/IMP)
Q92785 (/IMP)
Q92785 (/IMP)
Q92785 (/IMP)
Q92785 (/IMP)
Q92785 (/IMP)
Q92785 (/IMP)
Q92785 (/IMP)
Q92785 (/IMP)
(17 more) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
13 |
P56163 (/ISS)
P58267 (/ISS)
Q92782 (/ISS)
Q92782 (/ISS)
Q92782 (/ISS)
Q92782 (/ISS)
Q92782 (/ISS)
Q92782 (/ISS)
Q92782 (/ISS)
Q92782 (/ISS)
(3 more) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
3 | P58269 (/IMP) P58269 (/IMP) Q9QX66 (/IMP) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
1 | A9LMC0 (/ISS) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | A9LMC0 (/IMP) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
1 | P56163 (/IDA) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
1 | Q9QX66 (/ISO) |
|
Muscle organ morphogenesis GO:0048644
The process in which the anatomical structures of muscle are generated and organized.
|
1 | A9LMC0 (/IMP) |
|
Cardiac muscle tissue morphogenesis GO:0055008
The process in which the anatomical structures of cardiac muscle tissue are generated and organized.
|
1 | A9LMC0 (/IMP) |
|
Negative regulation of myeloid progenitor cell differentiation GO:1905454
Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation.
|
1 | Q61103 (/ISO) |
|
Negative regulation of myeloid progenitor cell differentiation GO:1905454
Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation.
|
1 | Q61103 (/ISS) |
There are 17 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
94 |
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
(84 more) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
79 |
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
(69 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
79 |
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
(69 more) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
79 |
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
A0A024R582 (/IDA)
(69 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
28 |
Q61103 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
(18 more) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
27 |
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
Q92785 (/HDA)
(17 more) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
27 |
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
Q92785 (/IDA)
(17 more) |
|
NBAF complex GO:0071565
A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
|
27 |
P56163 (/ISS)
Q92782 (/ISS)
Q92782 (/ISS)
Q92782 (/ISS)
Q92782 (/ISS)
Q92782 (/ISS)
Q92782 (/ISS)
Q92782 (/ISS)
Q92782 (/ISS)
Q92782 (/ISS)
(17 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | P58269 (/ISO) P58269 (/ISO) Q61103 (/ISO) |
|
NBAF complex GO:0071565
A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
|
3 | P58269 (/IDA) P58269 (/IDA) Q9QX66 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | Q61103 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q61103 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q61103 (/IDA) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
1 | Q61103 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q61103 (/ISO) |
|
SWI/SNF complex GO:0016514
A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof.
|
1 | A9LMC0 (/ISS) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | Q61103 (/ISO) |
