The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Zinc/RING finger domain, C3HC4 (zinc finger)
".
FunFam 43: Putative e3 ubiquitin-protein ligase march8
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
6 | Q5T0T0 (/IDA) Q5T0T0 (/IDA) Q6NZQ8 (/IDA) Q8TCQ1 (/IDA) Q9DBD2 (/IDA) Q9DBD2 (/IDA) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
6 | Q0VD59 (/ISS) Q28IK8 (/ISS) Q5XH39 (/ISS) Q9DBD2 (/ISS) Q9DBD2 (/ISS) Q9VSX7 (/ISS) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
3 | Q6NZQ8 (/ISO) Q9DBD2 (/ISO) Q9DBD2 (/ISO) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
3 | Q6NZQ8 (/IDA) Q9DBD2 (/IDA) Q9DBD2 (/IDA) |
|
MHC class II protein binding GO:0042289
Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
|
2 | Q9DBD2 (/IPI) Q9DBD2 (/IPI) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q9VSX7 (/ISM) |
|
MHC protein binding GO:0042287
Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
|
1 | Q8TCQ1 (/IDA) |
|
MHC protein binding GO:0042287
Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
|
1 | Q6NZQ8 (/ISO) |
|
MHC protein binding GO:0042287
Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
|
1 | Q6NZQ8 (/ISS) |
There are 10 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
6 | A0A286YAB5 (/IDA) A8KB30 (/IDA) B8A530 (/IDA) B8A531 (/IDA) Q9DBD2 (/IDA) Q9DBD2 (/IDA) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
4 | Q5T0T0 (/IDA) Q5T0T0 (/IDA) Q6NZQ8 (/IDA) Q8TCQ1 (/IDA) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
3 | Q6NZQ8 (/ISO) Q9DBD2 (/ISO) Q9DBD2 (/ISO) |
|
Antigen processing and presentation of peptide antigen via MHC class II GO:0002495
The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
|
3 | Q8TCQ1 (/IDA) Q9DBD2 (/IDA) Q9DBD2 (/IDA) |
|
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
2 | Q6NZQ8 (/IDA) Q8TCQ1 (/IDA) |
|
Negative regulation of MHC class II biosynthetic process GO:0045347
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.
|
2 | Q9DBD2 (/IDA) Q9DBD2 (/IDA) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
1 | Q9VSX7 (/ISS) |
|
Antigen processing and presentation of peptide antigen via MHC class II GO:0002495
The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
|
1 | Q6NZQ8 (/IMP) |
|
Antigen processing and presentation of peptide antigen via MHC class II GO:0002495
The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
|
1 | Q6NZQ8 (/ISO) |
|
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
1 | Q6NZQ8 (/ISO) |
There are 21 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
|
5 | Q0VD59 (/ISS) Q28IK8 (/ISS) Q5XH39 (/ISS) Q9DBD2 (/ISS) Q9DBD2 (/ISS) |
|
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
|
5 | Q0VD59 (/ISS) Q28IK8 (/ISS) Q5XH39 (/ISS) Q9DBD2 (/ISS) Q9DBD2 (/ISS) |
|
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
|
3 | Q5T0T0 (/IDA) Q5T0T0 (/IDA) Q8TCQ1 (/IDA) |
|
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
|
3 | Q6NZQ8 (/ISO) Q9DBD2 (/ISO) Q9DBD2 (/ISO) |
|
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
|
3 | Q5T0T0 (/IDA) Q5T0T0 (/IDA) Q8TCQ1 (/IDA) |
|
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
|
3 | Q6NZQ8 (/ISO) Q9DBD2 (/ISO) Q9DBD2 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q6NZQ8 (/ISS) Q9VSX7 (/ISS) |
|
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
2 | Q6NZQ8 (/IDA) Q8TCQ1 (/IDA) |
|
Late endosome membrane GO:0031902
The lipid bilayer surrounding a late endosome.
|
2 | Q6NZQ8 (/IDA) Q8TCQ1 (/IDA) |
|
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
|
1 | Q6NZQ8 (/IDA) |
|
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
|
1 | Q8TCQ1 (/ISS) |
|
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
1 | Q6NZQ8 (/IDA) |
|
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
1 | Q8TCQ1 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8TCQ1 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q6NZQ8 (/ISO) |
|
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
1 | Q6NZQ8 (/ISO) |
|
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
1 | Q9VSX7 (/ISS) |
|
Late endosome membrane GO:0031902
The lipid bilayer surrounding a late endosome.
|
1 | Q6NZQ8 (/ISO) |
|
Late endosome membrane GO:0031902
The lipid bilayer surrounding a late endosome.
|
1 | Q9VSX7 (/ISS) |
|
Trans-Golgi network membrane GO:0032588
The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.
|
1 | Q6NZQ8 (/IDA) |
|
Trans-Golgi network membrane GO:0032588
The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.
|
1 | Q8TCQ1 (/ISS) |
