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CATH Superfamily 3.30.390.50

CO dehydrogenase flavoprotein, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
CO dehydrogenase flavoprotein, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Lipoate--protein ligase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Lipoate--protein ligase. [EC: 6.3.1.20]
ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl- carrier protein]-N(6)-(lipoyl)lysine + AMP + diphosphate.
  • This enzyme participates in lipoate salvage, and is responsible for lipoylation in the presence of exogenous lipoic acid.
  • The enzyme attaches lipoic acid to the lipoyl domains of certain key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E(2) domain), 2-oxoglutarate dehydrogenase (E(2) domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein).
  • Lipoylation is essential for the function of these enzymes.
  • The enzyme can also use octanoate instead of lipoate.
  • Formerly EC 2.7.7.63.
 16 A0A0H3JLI5 A0A0H3JLI5 A0A0H3JLI5 A0A0H3JLI5 A0A0H3JR16 A0A0H3JR16 A0A0H3JR16 A0A0H3JR16 A0A2S4EPS9 A0A2S4EPS9
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