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CATH Superfamily 3.30.390.10

Enolase-like, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Enolase-like, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Gluconate dehydratase (GAD)

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Gluconate dehydratase. [EC: 4.2.1.39]
D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H(2)O.
  • The enzyme shows no activity with D-galactonate.
  • Cf. EC 4.2.1.140.
 11 A0A0E3MGU8 A0A0E3MGU8 A0A0E3MGU8 D0KR11 D0KR11 D0KR11 Q6L1T2 Q704D2 Q97U27 Q97U27
(1 more...)
Gluconate/galactonate dehydratase. [EC: 4.2.1.140]
(1) D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. (2) D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O.
  • The enzyme is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway in Picrophilus torridus and via the branched variant of the Entner- Doudoroff pathway in Sulfolobus solfataricus.
  • In vitro it utilizes D-gluconate with 6-10 fold higher catalytic efficiency than D-galactonate.
  • Cf. EC 4.2.1.6 and EC 4.2.1.39.
 10 A0A0E3MGU8 A0A0E3MGU8 A0A0E3MGU8 D0KR11 D0KR11 D0KR11 Q6L1T2 Q97U27 Q97U27 Q97U27
Galactonate dehydratase. [EC: 4.2.1.6]
D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O.
  • The enzyme shows no activity with D-gluconate.
  • Cf. EC 4.2.1.140.
 10 A0A0E3MGU8 A0A0E3MGU8 A0A0E3MGU8 D0KR11 D0KR11 D0KR11 Q6L1T2 Q97U27 Q97U27 Q97U27