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CATH Superfamily 3.30.300.110

Met-10+ protein-like domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Met-10+ protein-like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: tRNA wybutosine-synthesizing protein 2 homolog

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase. [EC: 2.5.1.114]
S-adenosyl-L-methionine + 4-demethylwyosine(37) in tRNA(Phe) = S-methyl- 5'-thioadenosine + 7-((3S)-3-amino-3-carboxypropyl)-4-demethylwyosine(37) in tRNA(Phe).
  • The enzyme, which is found in all eukaryotes and in the majority of Euryarchaeota (but not in the Crenarchaeota), is involved in the hypermodification of the guanine nucleoside at position 37 of tRNA leading to formation of assorted wye bases.
  • This modification is essential for translational reading-frame maintenance.
  • The eukaryotic enzyme is involved in biosynthesis of the tricyclic base wybutosine, which is found only in tRNA(Phe).
 6 Q0P466 Q4R3U8 Q4V8B8 Q53H54 Q58D65 Q8BG71
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