View in Gene3D

CATH Superfamily 3.30.300.10

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 2: GMP synthase [glutamine-hydrolyzing]

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
GMP synthase (glutamine-hydrolyzing). [EC: 6.3.5.2]
ATP + XMP + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.
  • Involved in the de novo biosynthesis of guanosine nucleotides.
  • An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain.
  • The enzyme can catalyze the second reaction alone in the presence of ammonia.
  • Formerly EC 6.3.4.1.
 21977 A0A015P660 A0A015P660 A0A015P660 A0A015P660 A0A015P660 A0A015P660 A0A015P660 A0A015P660 A0A015P660 A0A015P660
(21967 more...)