The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Eukaryotic translation initiation factor 2 subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
21 P41035 (/ISS) P41375 (/ISS) P41375 (/ISS) Q4R5G5 (/ISS) Q4R5G5 (/ISS) Q4R5G5 (/ISS) Q4R5G5 (/ISS) Q4R5G5 (/ISS) Q54T27 (/ISS) Q5E9D0 (/ISS)
(11 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 P09064 (/IPI) P09064 (/IPI) P20042 (/IPI) P20042 (/IPI) P20042 (/IPI) P20042 (/IPI) Q41969 (/IPI) Q6P685 (/IPI) Q99L45 (/IPI) Q99L45 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
8 Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
4 P20042 (/HDA) P20042 (/HDA) P20042 (/HDA) P20042 (/HDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
4 P20042 (/TAS) P20042 (/TAS) P20042 (/TAS) P20042 (/TAS)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
4 P20042 (/IDA) P20042 (/IDA) P20042 (/IDA) P20042 (/IDA)
Translation factor activity, RNA binding GO:0008135
Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome.
4 P20042 (/TAS) P20042 (/TAS) P20042 (/TAS) P20042 (/TAS)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
3 P56329 (/ISO) Q99L45 (/ISO) Q99L45 (/ISO)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
2 P09064 (/IDA) P09064 (/IDA)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
2 P09064 (/IMP) P09064 (/IMP)
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
2 P09064 (/IDA) P09064 (/IDA)
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
2 P09064 (/IPI) P09064 (/IPI)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
10 P41375 (/ISS) P41375 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS)
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
4 P20042 (/TAS) P20042 (/TAS) P20042 (/TAS) P20042 (/TAS)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
4 P20042 (/TAS) P20042 (/TAS) P20042 (/TAS) P20042 (/TAS)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
2 Q99L45 (/IMP) Q99L45 (/IMP)
Formation of translation preinitiation complex GO:0001731
The joining of the small ribosomal subunit, ternary complex, and mRNA.
2 P09064 (/IDA) P09064 (/IDA)
Formation of translation preinitiation complex GO:0001731
The joining of the small ribosomal subunit, ternary complex, and mRNA.
2 P09064 (/IMP) P09064 (/IMP)
Formation of translation preinitiation complex GO:0001731
The joining of the small ribosomal subunit, ternary complex, and mRNA.
2 P41375 (/ISS) P41375 (/ISS)
Male germ cell proliferation GO:0002176
The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population.
2 Q99L45 (/IMP) Q99L45 (/IMP)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
2 Q99L45 (/IMP) Q99L45 (/IMP)
Axon midline choice point recognition GO:0016199
The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.
2 P41375 (/IMP) P41375 (/IMP)
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
2 P41375 (/IMP) P41375 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q21230 (/IMP)
Cytoplasmic translational initiation GO:0002183
The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
1 P56329 (/ISO)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
1 Q21230 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q21230 (/IMP)
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
1 Q21230 (/IMP)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Eukaryotic translation initiation factor 2 complex GO:0005850
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.
10 P41375 (/ISS) P41375 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS) Q8IJT9 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 P20042 (/IDA) P20042 (/IDA) P20042 (/IDA) P20042 (/IDA) Q57Z81 (/IDA) Q57Z81 (/IDA)
Eukaryotic translation initiation factor 2 complex GO:0005850
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.
6 P09064 (/IDA) P09064 (/IDA) P20042 (/IDA) P20042 (/IDA) P20042 (/IDA) P20042 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P20042 (/TAS) P20042 (/TAS) P20042 (/TAS) P20042 (/TAS)
Eukaryotic translation initiation factor 2 complex GO:0005850
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.
4 P20042 (/TAS) P20042 (/TAS) P20042 (/TAS) P20042 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q4QIB4 (/ISO) Q99L45 (/ISO) Q99L45 (/ISO)
Eukaryotic translation initiation factor 2 complex GO:0005850
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.
3 P56329 (/ISO) Q99L45 (/ISO) Q99L45 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P41375 (/ISS) P41375 (/ISS)
Eukaryotic translation initiation factor 2 complex GO:0005850
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.
2 P09064 (/IMP) P09064 (/IMP)
Eukaryotic 43S preinitiation complex GO:0016282
A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
2 P09064 (/IDA) P09064 (/IDA)
Eukaryotic 43S preinitiation complex GO:0016282
A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
2 P41375 (/ISS) P41375 (/ISS)
Multi-eIF complex GO:0043614
A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.
2 P09064 (/IDA) P09064 (/IDA)
Multi-eIF complex GO:0043614
A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.
2 P41375 (/ISS) P41375 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P56329 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q41969 (/IDA)
Multi-eIF complex GO:0043614
A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.
1 P56329 (/ISO)