The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cullin; Chain C, Domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Cullin 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
16 A0A0G2K761 (/IPI) D4A0H4 (/IPI) O13790 (/IPI) Q13617 (/IPI) Q13617 (/IPI) Q13617 (/IPI) Q13617 (/IPI) Q13617 (/IPI) Q13617 (/IPI) Q13617 (/IPI)
(6 more)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
12 Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA)
(2 more)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 A0A0G2K761 (/IPI) D4A0H4 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 Q9V9R2 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 Q9D4H8 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q9D4H8 (/ISO)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
12 Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS)
(2 more)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
12 Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS)
(2 more)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
12 Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS)
(2 more)
Regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.
12 Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS)
(2 more)
Intrinsic apoptotic signaling pathway GO:0097193
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
12 Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS)
(2 more)
Vasculature development GO:0001944
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
2 A0A286Y8D7 (/IMP) E9QCA9 (/IMP)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
2 A0A286Y8D7 (/IMP) E9QCA9 (/IMP)
Reproduction GO:0000003
The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
1 Q17389 (/IMP)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 Q17389 (/IMP)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
1 Q9V9R2 (/IMP)
Growth of a germarium-derived egg chamber GO:0007295
Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster.
1 Q9V9R2 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q17389 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q17389 (/IMP)
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
1 Q17389 (/IMP)
Regulation of synaptic growth at neuromuscular junction GO:0008582
Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions.
1 Q9V9R2 (/IMP)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
1 Q17389 (/IMP)
Negative regulation of centrosome duplication GO:0010826
Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
1 Q17389 (/IMP)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
1 Q9V9R2 (/IC)
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
1 Q9D4H8 (/IMP)
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
1 Q9V9R2 (/IGI)
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
1 Q9V9R2 (/IMP)
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
1 O13790 (/IDA)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
1 Q17389 (/IMP)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
1 Q17389 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q17389 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q17389 (/IMP)
Negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518
Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
1 Q17389 (/IMP)
Negative regulation of mitotic cell cycle GO:0045930
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
1 Q17389 (/IMP)
Negative regulation of receptor signaling pathway via JAK-STAT GO:0046426
Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT.
1 Q9V9R2 (/IGI)
Male germ-line cyst encapsulation GO:0048140
Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the male gonad.
1 Q9V9R2 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 Q21346 (/IMP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
41 A0A0A0MTN0 (/IDA) A0A0A0MTN0 (/IDA) A0A0A0MTN0 (/IDA) A0A0A0MTN0 (/IDA) A0A0A0MTN0 (/IDA) A0A0A0MTN0 (/IDA) A0A140VKB1 (/IDA) A0A140VKB1 (/IDA) A0A140VKB1 (/IDA) A0A140VKB1 (/IDA)
(31 more)
Cul2-RING ubiquitin ligase complex GO:0031462
A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.
14 Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA) Q13617 (/IDA)
(4 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
12 Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS)
(2 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
12 Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS) Q13617 (/TAS)
(2 more)
VCB complex GO:0030891
A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.
2 A0A0G2K761 (/IDA) D4A0H4 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9D4H8 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9D4H8 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O13790 (/HDA)
SCF ubiquitin ligase complex GO:0019005
A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
1 O13790 (/IDA)
VCB complex GO:0030891
A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.
1 Q9D4H8 (/ISO)
Cul2-RING ubiquitin ligase complex GO:0031462
A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.
1 Q9D4H8 (/ISO)
Nuclear SCF ubiquitin ligase complex GO:0043224
A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
1 O13790 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q9V9R2 (/IDA)
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