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CATH Superfamily 3.30.230.130

Cullin; Chain C, Domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cullin; Chain C, Domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22: Anaphase-promoting complex subunit 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 5 Q12440 (/IPI) Q12440 (/IPI) Q12440 (/IPI) Q12440 (/IPI) Q12440 (/IPI)

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Metaphase/anaphase transition of mitotic cell cycle GO:0007091
The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
 5 Q12440 (/IGI) Q12440 (/IGI) Q12440 (/IGI) Q12440 (/IGI) Q12440 (/IGI)
Exit from mitosis GO:0010458
The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.
 5 Q12440 (/IGI) Q12440 (/IGI) Q12440 (/IGI) Q12440 (/IGI) Q12440 (/IGI)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
 5 Q12440 (/IMP) Q12440 (/IMP) Q12440 (/IMP) Q12440 (/IMP) Q12440 (/IMP)
Anaphase-promoting complex-dependent catabolic process GO:0031145
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.
 5 Q12440 (/IMP) Q12440 (/IMP) Q12440 (/IMP) Q12440 (/IMP) Q12440 (/IMP)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Anaphase-promoting complex GO:0005680
A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
 5 Q12440 (/IDA) Q12440 (/IDA) Q12440 (/IDA) Q12440 (/IDA) Q12440 (/IDA)