The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: DNA topoisomerase 4 subunit B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
102 P20083 (/IPI) P20083 (/IPI) P20083 (/IPI) P20083 (/IPI) P20083 (/IPI) P20083 (/IPI) P20083 (/IPI) P20083 (/IPI) P20083 (/IPI) P20083 (/IPI)
(92 more)
DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0003918
Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
9 Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS)
DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0003918
Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
3 Q9HUJ8 (/IDA) Q9HUJ8 (/IDA) Q9HUJ8 (/IDA)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
102 P20083 (/IMP) P20083 (/IMP) P20083 (/IMP) P20083 (/IMP) P20083 (/IMP) P20083 (/IMP) P20083 (/IMP) P20083 (/IMP) P20083 (/IMP) P20083 (/IMP)
(92 more)
Plasmid partitioning GO:0030541
Any process in which plasmids are segregated or distributed into daughter cells upon cell division.
102 P20083 (/IDA) P20083 (/IDA) P20083 (/IDA) P20083 (/IDA) P20083 (/IDA) P20083 (/IDA) P20083 (/IDA) P20083 (/IDA) P20083 (/IDA) P20083 (/IDA)
(92 more)
Chromosome organization GO:0051276
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
102 P20083 (/IMP) P20083 (/IMP) P20083 (/IMP) P20083 (/IMP) P20083 (/IMP) P20083 (/IMP) P20083 (/IMP) P20083 (/IMP) P20083 (/IMP) P20083 (/IMP)
(92 more)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
9 Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS)
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
9 Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS)
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
9 Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS)
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
3 Q9HUJ8 (/IDA) Q9HUJ8 (/IDA) Q9HUJ8 (/IDA)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
102 P20083 (/IDA) P20083 (/IDA) P20083 (/IDA) P20083 (/IDA) P20083 (/IDA) P20083 (/IDA) P20083 (/IDA) P20083 (/IDA) P20083 (/IDA) P20083 (/IDA)
(92 more)
DNA topoisomerase IV complex GO:0009340
A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA.
9 Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS) Q9KPD9 (/ISS)
DNA topoisomerase IV complex GO:0009340
A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA.
3 Q9HUJ8 (/IDA) Q9HUJ8 (/IDA) Q9HUJ8 (/IDA)
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